[HTML][HTML] Ceramides and ceramide scores: clinical applications for cardiometabolic risk stratification

M Hilvo, VC Vasile, LJ Donato, R Hurme… - Frontiers in …, 2020 - frontiersin.org
Ceramides are bioactive lipids that have an important role in many cellular functions such as
apoptosis and inflammation. During the past decade emerging clinical data have shown that …

[HTML][HTML] Exploring the lipidome: current lipid extraction techniques for mass spectrometry analysis

J Aldana, A Romero-Otero, MP Cala - Metabolites, 2020 - mdpi.com
In recent years, high-throughput lipid profiling has contributed to understand the biological,
physiological and pathological roles of lipids in living organisms. Across all kingdoms of life …

[HTML][HTML] High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

[HTML][HTML] Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories

A Triebl, B Burla, J Selvalatchmanan, J Oh, SH Tan… - Journal of lipid …, 2020 - ASBMB
Quantitative MS of human plasma lipids is a promising technology for translation into clinical
applications. Current MS-based lipidomic methods rely on either direct infusion (DI) or …

Development of a combined strategy for accurate lipid structural identification and quantification in ion-mobility mass spectrometry based untargeted lipidomics

X Chen, Y Yin, Z Zhou, T Li, ZJ Zhu - Analytica Chimica Acta, 2020 - Elsevier
Lipids are an important class of biomolecules, and play many essential functions in biology.
Ion mobility-mass spectrometry (IM-MS) has emerged as a promising technology for …

[HTML][HTML] Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study [S]

G Cadby, PE Melton, NS McCarthy, C Giles… - Journal of lipid …, 2020 - ASBMB
CVD is the leading cause of death worldwide, and genetic investigations into the human
lipidome may provide insight into CVD risk. The aim of this study was to estimate the …

[HTML][HTML] Male infertility: shining a light on lipids and lipid-modulating enzymes in the male germline

JLH Walters, BM Gadella, JM Sutherland… - Journal of clinical …, 2020 - mdpi.com
Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus
limiting treatment options and driving increased rates of recourse to assisted reproductive …

Profiling of lipidomics before and after antipsychotic treatment in first-episode psychosis

L Leppik, M Parksepp, S Janno, K Koido… - European Archives of …, 2020 - Springer
Alterations in complex lipids may be involved in pathophysiology of schizophrenia spectrum
disorders. Previously, we demonstrated importance of detecting lipid metabolism …

Exploring the mechanism underlying the cardioprotective effect of shexiang baoxin pill on acute myocardial infarction rats by comprehensive metabolomics

G Wu, L Chen, Y Gu, Y Hong, J Ma, N Zheng… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Shexiang Baoxin Pill (SBP) is a commercial
Chinese medicine included in the Chinese Pharmacopoeia with well-established …

Insights into the prognosis of lipidomic dysregulation for death risk in patients with coronary artery disease

M Qin, Q Zhu, W Lai, Q Ma, C Liu… - Clinical and …, 2020 - Wiley Online Library
Background Dyslipidaemia contributes to the progression of coronary artery disease (CAD)
toward adverse outcomes. Plasma lipidomic measure may improve the prognostic …