Breakthroughs in materials engineering have accelerated the progress of immunotherapy in
preclinical studies. The interplay of chemistry and materials has resulted in improved …

The growing demand for patient-compliance therapies in recent years has led to the
development of transdermal drug delivery, which possesses several advantages compared …

Transdermal microneedle patches have attracted significant attention in the medical arena
over the last decade as alternatives to traditional drug delivery methods. Microneedle …

In this study, the feasibility of transcutaneous immunization using different needle-
geometries dissolving microneedle array (DMNA) were investigated as drug carriers for …

In this study, dissolving microneedles (DMNs) with dual-release pattern, capable of both
bolus release and slow release, were prepared. These DMNs were used with a hepatitis B …

Introduction: In the last two decades, the evidence related to using vaccine patches with
multiple short projections (≤ 1 mm) to deliver vaccines through the skin increased …

The aim of this study was to develop and evaluate a novel route of administration for
vaccinating fish against Aeromonas hydrophila infection using a dissolving microneedles …

Transcutaneous immunization (TCI) is easy to use, minimally invasive, and has excellent
efficacy in vaccines against infections. We focused on toll-like receptor (TLR) ligands as …

The formulation of biotherapeutics presents unique challenges especially with regard to
physical and chemical stability and often requires refrigerated storage conditions of final …

抄録 手術用止血用シートには血液製剤が用いられることが多い. 止血性能の向上, 費用の抑制,
感染症リスクの低減などが求められている. 本研究ではフォトリソグラフィにより作製したマイクロ …