Poloxamer: A versatile tri-block copolymer for biomedical applications
Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers
containing central hydrophobic chains of poly (propylene oxide) sandwiched between two …
containing central hydrophobic chains of poly (propylene oxide) sandwiched between two …
Targeting anticancer drugs with pluronic aggregates: Recent updates
S Tiwari, V Kansara, P Bahadur - International Journal of Pharmaceutics, 2020 - Elsevier
Pluronics are triblock (PEO ab-PPO bb-PEO a) copolymers, commercially available in a
range of amphiphilicity. Usually, pluronics self-assemble in aqueous solution to form core …
range of amphiphilicity. Usually, pluronics self-assemble in aqueous solution to form core …
[HTML][HTML] Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Y Zhao, C Qiu, W Wang, J Peng, X Cheng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …
Pluronic micelles with suppressing doxorubicin efflux and detoxification for efficiently reversing breast cancer resistance
X Cheng, X Lv, J Xu, Y Zheng, X Wang… - European Journal of …, 2020 - Elsevier
The antitumor activity of doxorubicin (DOX) is often limited owing to the occurrence of
multidrug resistance (MDR) during treatment. Herein, we developed hybrid polymeric …
multidrug resistance (MDR) during treatment. Herein, we developed hybrid polymeric …
Toward understanding the prolonged circulation and elimination mechanism of crosslinked polymeric micelles in zebrafish model
Understanding the behaviors of nanomedicines in vivo is one of the most important
prerequisites for the design and optimization of nanomedicines. However, the in vivo …
prerequisites for the design and optimization of nanomedicines. However, the in vivo …
pH-sensitive pluronic micelles combined with oxidative stress amplification for enhancing multidrug resistance breast cancer therapy
X Cheng, X Zeng, Y Zheng, Q Fang, X Wang… - Journal of colloid and …, 2020 - Elsevier
Multidrug resistance (MDR) is one of the major obstacles to clinical cancer chemotherapy.
Herein, we designed new pH-sensitive pluronic micelles with the synergistic effects of …
Herein, we designed new pH-sensitive pluronic micelles with the synergistic effects of …
Novel folated pluronic F127 modified liposomes for delivery of curcumin: preparation, release, and cytotoxicity
Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes
with FA group on the surface, and evaluate the effects of FA-F127 modification on the …
with FA group on the surface, and evaluate the effects of FA-F127 modification on the …
Enhanced docetaxel delivery using sterically stabilized RIPL peptide-conjugated nanostructured lipid carriers: In vitro and in vivo antitumor efficacy against SKOV3 …
CH Kim, TH Kang, BD Kim, TH Lee, HY Yoon… - International Journal of …, 2020 - Elsevier
Docetaxel (DTX) has poor solubility, low specificity, and severe side effects. For efficient
targeting of DTX to hepsin-overexpressing SKOV3 ovarian cancer cells, PEGylated and …
targeting of DTX to hepsin-overexpressing SKOV3 ovarian cancer cells, PEGylated and …
Development and evaluation of polymeric micelle containing tablet formulation for poorly water-soluble drug: Tamoxifen citrate
Poor aqueous solubility is one of the key reasons for slow dissolution rate and poor
intestinal absorption and finally that causes low therapeutic efficacy of many existing drugs …
intestinal absorption and finally that causes low therapeutic efficacy of many existing drugs …
Structural and therapeutic properties of Pluronic® P123/F127 micellar systems and their modulation by salt and essential oil
Pluronics P123 and F127 mixed micellar system has been studied extensively for drug
delivery applications because of its non-toxic nature, good solubilization capacity of …
delivery applications because of its non-toxic nature, good solubilization capacity of …