[HTML][HTML] An emerging focus on lipids in extracellular vesicles

T Skotland, K Sagini, K Sandvig, A Llorente - Advanced drug delivery …, 2020 - Elsevier
Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated
material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular …

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

YY Jhan, D Prasca-Chamorro, GP Zuniga… - International journal of …, 2020 - Elsevier
The low yield of extracellular vesicle (EV) secretion is a major obstacle for mass production
and limits their potential for clinical applications as a drug delivery platform. Here, we mass …

The future of Extracellular Vesicles as Theranostics–an ISEV meeting report

C Soekmadji, B Li, Y Huang, H Wang, T An, C Liu… - 2020 - Taylor & Francis
The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in
the past decade. In November 2018, the International Society for Extracellular Vesicles …

Functional assays to assess the therapeutic potential of extracellular vesicles

VVT Nguyen, KW Witwer, MC Verhaar… - Journal of …, 2020 - Wiley Online Library
An important aspect in the development of extracellular vesicle (EV) therapeutics is
identifying and quantifying the key features defining their identity, purity, sterility, potency …

[HTML][HTML] Exosomes in head and neck cancer: Roles, mechanisms and applications

J Cao, M Zhang, F Xie, J Lou, X Zhou, L Zhang, M Fang… - Cancer Letters, 2020 - Elsevier
Exosomes are extracellular vesicles with a diameter of 30–100 nm that exist stably in
various body fluids, including the blood, cerebrospinal fluid, urine, saliva, and serous cavity …

[HTML][HTML] Capillary zone electrophoresis of bacterial extracellular vesicles: A proof of concept

M Piotrowska, K Ciura, M Zalewska, M Dawid… - … of Chromatography A, 2020 - Elsevier
The extracellular vesicles (EVs) released by plant pathogens of the Pectobacterium genus
were investigated. The isolates were obtained using differential centrifugation followed by …

Challenges of manufacturing mesenchymal stromal cell–derived extracellular vesicles in regenerative medicine

EF Wiest, AC Zubair - Cytotherapy, 2020 - Elsevier
The field of regenerative medicine has expanded greatly in the past decade, with more than
1000 current clinical trials involving mesenchymal stromal cell (MSC) treatment. Multiple …

Cell-free extracellular vesicles derived from human bone marrow endothelial progenitor cells as potential therapeutics for microvascular endothelium restoration in …

S Garbuzova-Davis, AE Willing, J Ehrhart… - Neuromolecular …, 2020 - Springer
Repairing the damaged blood-CNS-barrier in amyotrophic lateral sclerosis (ALS) is
necessary to prevent entry of detrimental blood-borne factors contributing to motor neuron …

Extracellular vesicles as potential prognostic markers of lymphatic dysfunction

A Milasan, M Farhat, C Martel - Frontiers in physiology, 2020 - frontiersin.org
Despite significant efforts made to treat cardiovascular disease (CVD), more than half of
cardiovascular events still occur in asymptomatic subjects devoid of traditional risk factors …