Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly (A)-binding protein Nab2
RNA-binding proteins (RBPs) are key mediators of RNA metabolism. Whereas some RBPs
exhibit narrow transcript specificity, others function broadly across both coding and non …
exhibit narrow transcript specificity, others function broadly across both coding and non …
RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination
JF Victorino, MJ Fox, WR Smith-Kinnaman… - PLoS …, 2020 - journals.plos.org
RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation
status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate …
status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate …
NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics
In yeast, NuA3 histone acetyltransferase (NuA3 HAT) promotes acetylation of histone H3
lysine 14 (H3K14) and transcription of a subset of genes through interaction between the …
lysine 14 (H3K14) and transcription of a subset of genes through interaction between the …
A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation
Abstract The Nrd1–Nab3–Sen1 (NNS) complex integrates molecular cues to direct
termination of noncoding transcription in budding yeast. NNS is positively regulated by …
termination of noncoding transcription in budding yeast. NNS is positively regulated by …
Enhancers regulate polyadenylation site cleavage and control 3′ UTR isoform expression
Enhancers are DNA elements that increase gene expression. mRNA production is
determined by transcript production and polyadenylation site (PAS) cleavage activity. We …
determined by transcript production and polyadenylation site (PAS) cleavage activity. We …
Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and widespread in trans effects on the protein regulatory …
LN Balarezo-Cisneros, S Parker, MG Fraczek… - bioRxiv, 2020 - biorxiv.org
Abstract Non-coding RNAs (ncRNAs), including the more recently identified Stable
Unannotated Transcripts (SUTs) and Cryptic Unstable Transcripts (CUTs), are increasingly …
Unannotated Transcripts (SUTs) and Cryptic Unstable Transcripts (CUTs), are increasingly …
A Budding Yeast Model for Human Disease Mutations in the EXOSC2 Cap Subunit of the RNA Exosome
MC Sterrett, L Enyenihi, SW Leung, L Hess… - bioRxiv, 2020 - biorxiv.org
RNA exosomopathies, a growing family of tissue-specific diseases, are linked to missense
mutations in genes encoding the structural subunits of the highly conserved 10-subunit …
mutations in genes encoding the structural subunits of the highly conserved 10-subunit …
[PDF][PDF] Gene Regulation in Saccharomyces cerevisiae: the role of NAD+ metabolism and non-coding RNAs in protein-coding genes
L Balarezo Cisneros - 2020 - pure.manchester.ac.uk
Chromatin plays critical roles in regulating transcription. It needs to be accessible to allow
the binding of specific regulators such as transcription factors and other gene regulatory …
the binding of specific regulators such as transcription factors and other gene regulatory …