The modified WHO analgesic ladder: is it appropriate for chronic non-cancer pain?
Introduction From 1986, the World Health Organization (WHO) analgesic ladder has been
used as the simple and valuable pain-relieving guidance in the pharmaceutical pain …
used as the simple and valuable pain-relieving guidance in the pharmaceutical pain …
[HTML][HTML] Drivers of the opioid crisis: an appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing
S Spithoff, P Leece, F Sullivan, N Persaud, P Belesiotis… - PloS one, 2020 - journals.plos.org
Background Starting in the late 1990s, the pharmaceutical industry sought to increase
prescribing of opioids for chronic non-cancer pain. Influencing the content of clinical practice …
prescribing of opioids for chronic non-cancer pain. Influencing the content of clinical practice …
Replacement of current opioid drugs focusing on MOR-related strategies
The scarcity and limited risk/benefit ratio of painkillers available on the market, in addition to
the opioid crisis, warrant reflection on new innovation strategies. The pharmacopoeia of …
the opioid crisis, warrant reflection on new innovation strategies. The pharmacopoeia of …
Management of opioid use disorder in the emergency department: a white paper prepared for the American Academy of Emergency Medicine
Over 2 million Americans misuse prescription or illicitly obtained opioids, and opioid
overdose deaths rose to a record 47,600 in 2017, representing a nearly 600% increase in …
overdose deaths rose to a record 47,600 in 2017, representing a nearly 600% increase in …
[HTML][HTML] “My life is under control with these medications”: an interpretative phenomenological analysis of managing chronic pain with opioids
H Ljungvall, A Rhodin, S Wagner, H Zetterberg… - BMC musculoskeletal …, 2020 - Springer
Background The use of opioids to relieve chronic pain has increased during the last
decades, but experiences of chronic opioid therapy (COT)(> 90 days) point at risks and loss …
decades, but experiences of chronic opioid therapy (COT)(> 90 days) point at risks and loss …
Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor …
WN Jiang, X Jing, M Li, H Deng, T Jiang… - European Journal of …, 2020 - Elsevier
Corydalis is a Chinese herb that has been used in China for hundreds of years for analgesic
and other purposes. Corydaline and l-tetrahydropalmatine (l-THP) are the main active …
and other purposes. Corydaline and l-tetrahydropalmatine (l-THP) are the main active …
Efficacy of a psychosocial pain management intervention for men and women with substance use disorders and chronic pain: A randomized clinical trial
Importance Chronic pain is common in those with substance use disorders (SUDs) and
predicts poorer addiction treatment outcomes. A critical challenge for addiction treatment is …
predicts poorer addiction treatment outcomes. A critical challenge for addiction treatment is …
[HTML][HTML] Increased risk of adverse events in non-cancer patients with chronic and high-dose opioid use—A health insurance claims analysis
Background Chronic and high dose opioid use may result in adverse events. We analyzed
the risk associated with chronic and high dose opioid prescription in a Swiss population …
the risk associated with chronic and high dose opioid prescription in a Swiss population …
[HTML][HTML] Increasing system-wide implementation of opioid prescribing guidelines in primary care: findings from a non-randomized stepped-wedge quality improvement …
AE Zgierska, JM Robinson, RP Lennon, PD Smith… - BMC Family …, 2020 - Springer
Background Clinician utilization of practice guidelines can reduce inappropriate opioid
prescribing and harm in chronic non-cancer pain; yet, implementation of “opioid guidelines” …
prescribing and harm in chronic non-cancer pain; yet, implementation of “opioid guidelines” …
[HTML][HTML] Chronic non-malignant pain in patients with cancer seen at a timely outpatient palliative care clinic
Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of
chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In …
chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In …