Mass spectrometry imaging is a field that promises to become a mainstream bioanalysis
technology by allowing the combination of single-cell imaging and subcellular quantitative …

The development of improved or targeted drugs that discriminate between normal and tumor
tissues is the key therapeutic issue in cancer research. However, the development of an …

Rationale: Optimal intratumor distribution of an anticancer drug is fundamental to reach an
active concentration in neoplastic cells, ensuring the therapeutic effect. Determination of …

In quantitative mass spectrometry imaging (MSI), the gold standard adds a single structural
homologue of the target compound at a known concentration to the sample. This internal …

Mass spectrometry imaging (MSI) plays a pivotal role in investigating the chemical nature of
complex systems that underly our understanding in biology and medicine. Multiple fields of …

The matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI)
technique has attracted intense interest in the visualization of drug distribution in tissues. Its …

Penetration of nanoparticles into viable tumor regions is essential for an effective response.
Mass spectrometry imaging (MSI) is a novel method for evaluating the intratumoral …

Current histology techniques, such as tissue staining or histochemistry protocols, provide
very limited chemical information about the tissues. Chemical imaging technologies such as …

Tissue sections have long been the subject matter for the application of imaging mass
spectrometry, but recently the technique has been adapted for many other purposes …

A time-dependent postextraction differential acceleration (PEDA) potential was used to
temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing …