Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Mucopolysaccharidosis type I (MPS I) is a rare autosomal recessive inherited disease,
caused by deficiency of the enzyme α-L-iduronidase, resulting in accumulation of the …

Over the past few decades, understanding how tumor cells evade the immune system and
their communication with their tumor microenvironment, has been the subject of intense …

The eicosanoid leukotriene B 4 (LTB 4) relays chemotactic signals to direct neutrophil
migration to inflamed sites through its receptor BLT1. However, the mechanisms by which …

Background Recent studies have highlighted a critical role for a group of natriuretic
hormones, cardiotonic steroid (CTS), in mediating renal inflammation and fibrosis …

This chapter describes the chemokine structures that have been determined to date and
discusses the structural differences in terms of observed functional differences between the …

This chapter describes the molecular and cellular mechanisms of chemokine-induced
leukocyte-endothelial cell adhesion and deliberate on how soluble and immobilized …

This chapter discusses recent highlights of the role of integrins in T-cell trafficking and T-cell
responses, with a particular emphasis on the signaling functions of integrins. A …

Modern chemotherapy can be effective in the total elimination of tumors in some cancers,
but is now thought to have little benefit for many patients with early stage and low risk breast …

Due to their great specificity and regulatory role in nearly all cellular processes, G protein-
coupled receptors (GPCR) are a common therapeutic target. Investigating the molecular …