Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
Implementing the new European Regulations on medical devices—clinical responsibilities for evidence-based practice: a report from the Regulatory Affairs Committee …
AG Fraser, RA Byrne, J Kautzner… - European heart …, 2020 - academic.oup.com
Abstract The new European Union (EU) law governing the regulatory approval of medical
devices that entered into force in May 2017 will now take effect from 26 May 2021. Here, we …
devices that entered into force in May 2017 will now take effect from 26 May 2021. Here, we …
In vitro platform establishes antigen-specific CD8+ T cell cytotoxicity to encapsulated cells via indirect antigen recognition
Y Li, AW Frei, EY Yang, I Labrada-Miravet, C Sun… - Biomaterials, 2020 - Elsevier
The curative potential of non-autologous cellular therapy is hindered by the requirement of
anti-rejection therapy. Cellular encapsulation within nondegradable biomaterials has the …
anti-rejection therapy. Cellular encapsulation within nondegradable biomaterials has the …
Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice
T Watanabe, T Okitsu, F Ozawa, S Nagata, H Matsunari… - Biomaterials, 2020 - Elsevier
Transplantation technologies of pancreatic islets as well as stem cell-derived pancreatic
beta cells encapsulated in hydrogel for the induction of immunoprotection could advance to …
beta cells encapsulated in hydrogel for the induction of immunoprotection could advance to …
Applications of alginate biopolymer in drug delivery
Alginates are ubiquitous in the fields of biomaterials science and drug delivery. These
polysaccharides are versatile due to their biocompatibility and structural functionality. This …
polysaccharides are versatile due to their biocompatibility and structural functionality. This …
Recent advances in anti-inflammatory strategies for implantable biosensors and medical implants
Due to the global aging at an accelerated rate, demands for medical implants have been
rapidly increasing. Consequently, a number of complications associated with medical …
rapidly increasing. Consequently, a number of complications associated with medical …
Parallel evolution of polymer chemistry and immunology: integrating mechanistic biology with materials design
K Sadtler, J Collins, JD Byrne, R Langer - Advanced drug delivery reviews, 2020 - Elsevier
To develop new therapeutics involves the interaction of multiple disciplines to yield safe,
functional devices and formulations. Regardless of drug function and potency …
functional devices and formulations. Regardless of drug function and potency …
Design of an adhesive film-based microfluidic device for alginate hydrogel-based cell encapsulation
To support the increasing translational use of transplanted cells, there is a need for high-
throughput cell encapsulation technologies. Microfluidics is a particularly promising …
throughput cell encapsulation technologies. Microfluidics is a particularly promising …
Bioengineering, biomaterials, and β-cell replacement therapy
R De Vries, A Stell, S Mohammed, C Hermanns… - … , and Regeneration of …, 2020 - Elsevier
The field of biomaterials, regenerative medicine, and bioengineering has in the last decade
connected with islet transplantation research. This chapter describes some of the more …
connected with islet transplantation research. This chapter describes some of the more …
Development of a novel oral delivery vehicle for probiotics
Background: There is a significant interest in effective oral drug delivery of therapeutic
substances. For probiotics, there is a particular need for a delivery platform that protects the …
substances. For probiotics, there is a particular need for a delivery platform that protects the …