Use of family history and genetic testing to determine risk of colorectal cancer
F Kastrinos, NJ Samadder, RW Burt - Gastroenterology, 2020 - Elsevier
Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …
disease attributed to genetic factors, common exposures, or both. Some families with a …
[HTML][HTML] Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
Population genetic screening efficiently identifies carriers of autosomal dominant diseases
JJ Grzymski, G Elhanan, JA Morales Rosado, E Smith… - Nature medicine, 2020 - nature.com
Three inherited autosomal dominant conditions—BRCA-related hereditary breast and
ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH) …
ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH) …
Expanding the scope of immunotherapy in colorectal cancer: current clinical approaches and future directions
M Kreidieh, D Mukherji, S Temraz… - BioMed research …, 2020 - Wiley Online Library
The success of immune checkpoint inhibitors (ICIs) in an increasing range of heavily
mutated tumor types such as melanoma has culminated in their exploration in different …
mutated tumor types such as melanoma has culminated in their exploration in different …
Association of rare pathogenic DNA variants for familial hypercholesterolemia, hereditary breast and ovarian cancer syndrome, and lynch syndrome with disease risk …
Importance Pathogenic DNA variants associated with familial hypercholesterolemia,
hereditary breast and ovarian cancer syndrome, and Lynch syndrome are widely recognized …
hereditary breast and ovarian cancer syndrome, and Lynch syndrome are widely recognized …
Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types
Microsatellites are repeats of 1-to 6-bp units, and approximately 10 million microsatellites
have been identified across the human genome. Microsatellites are vulnerable to DNA …
have been identified across the human genome. Microsatellites are vulnerable to DNA …
A new comprehensive colorectal cancer risk prediction model incorporating family history, personal characteristics, and environmental factors
Purpose: Reducing colorectal cancer incidence and mortality through early detection would
improve efficacy if targeted. We developed a colorectal cancer risk prediction model …
improve efficacy if targeted. We developed a colorectal cancer risk prediction model …
BRCA and Beyond: Comprehensive Image-rich Review of Hereditary Breast and Gynecologic Cancer Syndromes
SH Chung, N Woldenberg, AR Roth, R Masamed… - Radiographics, 2020 - pubs.rsna.org
In addition to the well-characterized BRCA1 and BRCA2 hereditary breast and ovarian
cancer syndromes, many other syndromes that are associated with genetic mutations …
cancer syndromes, many other syndromes that are associated with genetic mutations …
Risk of metachronous colorectal neoplasm after a segmental colectomy in Lynch syndrome patients according to mismatch repair gene status
FF Quezada-Diaz, I Hameed… - Journal of the …, 2020 - journals.lww.com
BACKGROUND: Because of increased risk of metachronous colorectal cancer (CRC), all
patients with Lynch syndrome (LS) are offered a total colectomy. However, because …
patients with Lynch syndrome (LS) are offered a total colectomy. However, because …
Genomic variation as a marker of response to neoadjuvant therapy in locally advanced rectal cancer
JK Douglas, RE Callahan, ZA Hothem… - Molecular & cellular …, 2020 - Taylor & Francis
There is variation in the responsiveness of locally advanced rectal cancer to neoadjuvant
chemoradiation, from complete response to total resistance. This study compared genetic …
chemoradiation, from complete response to total resistance. This study compared genetic …