Biomarkers in triple-negative breast cancer: state-of-the-art and future perspectives

S Cocco, M Piezzo, A Calabrese, D Cianniello… - International journal of …, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by
aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is still …

Poly (ADP-ribose) polymerase inhibitors in prostate cancer: molecular mechanisms, and preclinical and clinical data

D Sigorski, E Iżycka-Świeszewska, L Bodnar - Targeted Oncology, 2020 - Springer
Genomic instability is one of the hallmarks of cancer. The incidence of genetic alterations in
homologous recombination repair genes increases during cancer progression, and 20% of …

Update on the role of poly (ADP-ribose) polymerase inhibitors in the DNA repair-deficient pancreatic cancers: a narrative review

A Kasi, M Al-Jumayli, R Park, J Baranda… - Journal of Pancreatic …, 2020 - liebertpub.com
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most common cancer found in
the pancreas. It has a dismal prognosis and current therapeutic options, including surgical …

Olaparib is effective for recurrent urothelial carcinoma with BRCA2 pathogenic germline mutation: first report on olaparib response in recurrent UC

H Yang, Z Liu, Y Wang, J Li, R Li… - Therapeutic …, 2020 - journals.sagepub.com
Urothelial carcinoma (UC) is a common malignancy of the lower and upper urinary tract.
Recurrent UC has poor prognosis due to delayed diagnosis and a lack of clinical …

Sensitivity profile of triple-negative breast cancer cell lines to combination therapies including RANKL blockade

JBCC Belo - 2020 - search.proquest.com
O cancro da mama (CM) é o cancro com a segunda mais elevada mortalidade a nível
mundial. Dada a heterogeneidade que apresenta, é classificado em subtipos de acordo …