Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease
Rheumatoid arthritis (RA) is characterized by immune dysfunctions and chronic
inflammation that mainly affects diarthrodial joints. Genetics has long been surveyed in …
inflammation that mainly affects diarthrodial joints. Genetics has long been surveyed in …
Clinical significance of miRNAs in autoimmunity
MicroRNAs (miRNAs) are evolutionally conserved, single-stranded RNAs that regulate gene
expression at the posttranscriptional level by disrupting translation. MiRNAs are key players …
expression at the posttranscriptional level by disrupting translation. MiRNAs are key players …
Exosomes: Effectual players in rheumatoid arthritis
F Tavasolian, AS Moghaddam, F Rohani… - Autoimmunity …, 2020 - Elsevier
Rheumatoid arthritis is a well-known chronic inflammatory joint disorder. It encompasses
systemic inflammation, autoimmunity and development of several joint abnormalities leading …
systemic inflammation, autoimmunity and development of several joint abnormalities leading …
The inhibition by human MSCs-derived miRNA-124a overexpression exosomes in the proliferation and migration of rheumatoid arthritis-related fibroblast-like …
HY Meng, LQ Chen, LH Chen - BMC Musculoskeletal Disorders, 2020 - Springer
Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is
characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in …
characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in …
Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis
ZM Wu, J Luo, XD Shi, SX Zhang, XB Zhu, J Guo - Autoimmunity, 2020 - Taylor & Francis
Rheumatoid arthritis (RA) is considered to be a chronic autoimmune disease, pathogenesis
of RA is complex and effective treatments for RA is still lacking. Previous studies found that …
of RA is complex and effective treatments for RA is still lacking. Previous studies found that …
MicroRNAs in synovial pathology associated with osteoarthritis
G Tavallaee, JS Rockel, S Lively, M Kapoor - Frontiers in medicine, 2020 - frontiersin.org
Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint.
The relative involvement of each tissue, and their interactions, add to the complexity of OA …
The relative involvement of each tissue, and their interactions, add to the complexity of OA …
[HTML][HTML] Dysregulation of non-coding RNAs in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that is associated with both
genetic and environmental factors. Dysregulation of the immune response is the main …
genetic and environmental factors. Dysregulation of the immune response is the main …
Small and long non-coding RNAs as functional regulators of bone homeostasis, acting alone or cooperatively
M Sikora, K Marycz, A Smieszek - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Emerging knowledge indicates that non-coding RNAs, including microRNAs (miRNAs) and
long-noncoding RNAs (lncRNAs), have a pivotal role in bone development and the …
long-noncoding RNAs (lncRNAs), have a pivotal role in bone development and the …
Altered expression of microRNAs may predict therapeutic response in rheumatoid arthritis patients
M Rezaeepoor, M Pourjafar… - International …, 2020 - Elsevier
Background Epigenetic alternations of microRNAs (miRNAs) can contribute to the
pathogenesis and progression of rheumatoid arthritis (RA). This study aimed to measure the …
pathogenesis and progression of rheumatoid arthritis (RA). This study aimed to measure the …