Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease

J Karami, S Aslani, MN Tahmasebi… - Immunology and cell …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is characterized by immune dysfunctions and chronic
inflammation that mainly affects diarthrodial joints. Genetics has long been surveyed in …

Clinical significance of miRNAs in autoimmunity

L Zhang, H Wu, M Zhao, C Chang, Q Lu - Journal of autoimmunity, 2020 - Elsevier
MicroRNAs (miRNAs) are evolutionally conserved, single-stranded RNAs that regulate gene
expression at the posttranscriptional level by disrupting translation. MiRNAs are key players …

Exosomes: Effectual players in rheumatoid arthritis

F Tavasolian, AS Moghaddam, F Rohani… - Autoimmunity …, 2020 - Elsevier
Rheumatoid arthritis is a well-known chronic inflammatory joint disorder. It encompasses
systemic inflammation, autoimmunity and development of several joint abnormalities leading …

The inhibition by human MSCs-derived miRNA-124a overexpression exosomes in the proliferation and migration of rheumatoid arthritis-related fibroblast-like …

HY Meng, LQ Chen, LH Chen - BMC Musculoskeletal Disorders, 2020 - Springer
Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is
characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in …

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis

ZM Wu, J Luo, XD Shi, SX Zhang, XB Zhu, J Guo - Autoimmunity, 2020 - Taylor & Francis
Rheumatoid arthritis (RA) is considered to be a chronic autoimmune disease, pathogenesis
of RA is complex and effective treatments for RA is still lacking. Previous studies found that …

MicroRNAs in synovial pathology associated with osteoarthritis

G Tavallaee, JS Rockel, S Lively, M Kapoor - Frontiers in medicine, 2020 - frontiersin.org
Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint.
The relative involvement of each tissue, and their interactions, add to the complexity of OA …

[HTML][HTML] Dysregulation of non-coding RNAs in rheumatoid arthritis

M Taheri, R Eghtedarian, ME Dinger… - Biomedicine & …, 2020 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that is associated with both
genetic and environmental factors. Dysregulation of the immune response is the main …

Small and long non-coding RNAs as functional regulators of bone homeostasis, acting alone or cooperatively

M Sikora, K Marycz, A Smieszek - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Emerging knowledge indicates that non-coding RNAs, including microRNAs (miRNAs) and
long-noncoding RNAs (lncRNAs), have a pivotal role in bone development and the …

Altered expression of microRNAs may predict therapeutic response in rheumatoid arthritis patients

M Rezaeepoor, M Pourjafar… - International …, 2020 - Elsevier
Background Epigenetic alternations of microRNAs (miRNAs) can contribute to the
pathogenesis and progression of rheumatoid arthritis (RA). This study aimed to measure the …