Sialylation and galectin-3 in microglia-mediated neuroinflammation and neurodegeneration

M Puigdellívol, DH Allendorf, GC Brown - Frontiers in cellular …, 2020 - frontiersin.org
Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …

Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies

SE Williams, RG Mealer, EM Scolnick, JW Smoller… - Molecular …, 2020 - nature.com
Glycosylation, the enzymatic attachment of carbohydrates to proteins and lipids, regulates
nearly all cellular processes and is critical in the development and function of the nervous …

Post-translational protein modifications in schizophrenia

TM Mueller, JH Meador-Woodruff - npj Schizophrenia, 2020 - nature.com
Research investigating the pathophysiology of schizophrenia has not yet precisely defined
the molecular phenotype of this disorder. Many studies have investigated cellular …

The neuroplasticity marker PSA-NCAM: Insights into new therapeutic avenues for promoting neuroregeneration

V Saini, T Kaur, S Kalotra, G Kaur - Pharmacological Research, 2020 - Elsevier
Neuroplastic alterations are the key processes involved in adaptation and rehabilitation after
all neurological injuries and pathologies. Being the central contributor to the developmental …

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

A Bacq, S Astori, E Gebara, W Tang, BA Silva… - Molecular …, 2020 - nature.com
Aggression is frequently observed in neurodevelopmental psychiatric disorders such as
schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying …

Cellautonomous impact of polysialic acidproducing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons

UE Schuster, C Rossdam, I Röckle… - Journal of …, 2020 - Wiley Online Library
In humans, variations in the polysialic acidproducing enzyme ST8SIA2 and disturbances in
the cortical inhibitory system are associated with neurodevelopmental psychiatric disorders …

Sialic acid-containing molecules in drug discovery and development

P Bose, AK Agrahari, AS Singh, MK Jaiswal… - Carbohydrates in Drug …, 2020 - Elsevier
In nature, all cells are covered with a complex array of carbohydrates particularly sialic acids
which is chemically a negatively charged nine-carbon α-keto aldonic acids. Because of their …