Sialylation and galectin-3 in microglia-mediated neuroinflammation and neurodegeneration
M Puigdellívol, DH Allendorf, GC Brown - Frontiers in cellular …, 2020 - frontiersin.org
Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …
Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies
SE Williams, RG Mealer, EM Scolnick, JW Smoller… - Molecular …, 2020 - nature.com
Glycosylation, the enzymatic attachment of carbohydrates to proteins and lipids, regulates
nearly all cellular processes and is critical in the development and function of the nervous …
nearly all cellular processes and is critical in the development and function of the nervous …
Post-translational protein modifications in schizophrenia
TM Mueller, JH Meador-Woodruff - npj Schizophrenia, 2020 - nature.com
Research investigating the pathophysiology of schizophrenia has not yet precisely defined
the molecular phenotype of this disorder. Many studies have investigated cellular …
the molecular phenotype of this disorder. Many studies have investigated cellular …
The neuroplasticity marker PSA-NCAM: Insights into new therapeutic avenues for promoting neuroregeneration
Neuroplastic alterations are the key processes involved in adaptation and rehabilitation after
all neurological injuries and pathologies. Being the central contributor to the developmental …
all neurological injuries and pathologies. Being the central contributor to the developmental …
Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency
Aggression is frequently observed in neurodevelopmental psychiatric disorders such as
schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying …
schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying …
Cellautonomous impact of polysialic acidproducing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons
UE Schuster, C Rossdam, I Röckle… - Journal of …, 2020 - Wiley Online Library
In humans, variations in the polysialic acidproducing enzyme ST8SIA2 and disturbances in
the cortical inhibitory system are associated with neurodevelopmental psychiatric disorders …
the cortical inhibitory system are associated with neurodevelopmental psychiatric disorders …
Sialic acid-containing molecules in drug discovery and development
P Bose, AK Agrahari, AS Singh, MK Jaiswal… - Carbohydrates in Drug …, 2020 - Elsevier
In nature, all cells are covered with a complex array of carbohydrates particularly sialic acids
which is chemically a negatively charged nine-carbon α-keto aldonic acids. Because of their …
which is chemically a negatively charged nine-carbon α-keto aldonic acids. Because of their …