Protein S is a critical regulator of coagulation that functions as a cofactor for the activated
protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct …

Novel approaches to the treatment of haemophilia are needed due to the limitations of the
current standard of care, factor replacement therapy. Aspirations include lessening the …

Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis Guidelines
on the laboratory aspects of assays used in haemostasis and thrombosis Br J Haematol. 2020 …

Thrombotic complications and hypercoagulopathies are commonly associated with the
progression of pancreatic ductal adenocarcinoma (PDAC). Although the mechanistic link …

Anticoagulant protein S (PS) in platelets (PSplt) resembles plasma PS and is released on
platelet activation, but its role in thrombosis has not been elucidated. Here we report that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a
global pandemic. In addition to the acute pulmonary symptoms of COVID-19 (the disease …

Background Increasing evidence for contribution of hemostasis components in multiple
sclerosis (MS) has been reported. Hemostasis protein inhibitors display key regulatory roles …

Aims Hereditary protein S (PS) deficiency is one of the natural anticoagulant deficiencies
causing thrombophilia. We herein described a young male with recurrent deep venous …

Hemostasis is a complex physiological process requiring interaction of the coagulation
system proteins, platelets, and components of the vessel wall to maintain blood in a fluid …

Engineered Soluble Protein C Pathway Receptors as Novel Pro-Haemostatic Agents Page
1 Royal College of Surgeons in Ireland repository@rcsi.com Engineered Soluble Protein C …