[HTML][HTML] Obesity and NRF2-mediated cytoprotection: Where is the missing link?

LV Vasileva, MS Savova, KM Amirova… - Pharmacological …, 2020 - Elsevier
The expanding dimensions of the global health crisis of overweight population has defined
the term “globesity”. Among the most common pathological conditions connected with …

The immune system on the TRAIL of Alzheimer's disease

C Burgaletto, A Munafò, G Di Benedetto… - Journal of …, 2020 - Springer
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive degeneration and loss of neurons in specific regions of the central nervous …

Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

S Meyer zu Reckendorf, C Brand, MT Pedro… - Nature …, 2020 - nature.com
Mammals differ in their regeneration potential after traumatic injury, which might be caused
by species-specific regeneration programs. Here, we compared murine and human …

MicroRNA‐181a exerts anti‐inflammatory effects via inhibition of the ERK pathway in mice with intervertebral disc degeneration

Y Sun, X Shi, X Peng, Y Li, H Ma, D Li… - Journal of Cellular …, 2020 - Wiley Online Library
Enzymatic decomposition of extracellular matrix and possibly local inflammation may cause
intervertebral disc degeneration (IDD). MicroRNAs have been reported to correlate with the …

A trail-tl1a paracrine network involving adipocytes, macrophages, and lymphocytes induces adipose tissue dysfunction downstream of e2f1 in human obesity

N Maixner, T Pecht, Y Haim, V Chalifa-Caspi… - Diabetes, 2020 - Am Diabetes Assoc
Elevated expression of E2F1 in adipocyte fraction of human visceral adipose tissue (hVAT)
associates with a poor cardiometabolic profile. We hypothesized that beyond directly …

Impaired circulating CD56dim NK cells are associated with decompensation of HBV-related cirrhosis

Y Jiang, Y Chen, L Chen, W Yao, J Guan, X Liu… - Human Immunology, 2020 - Elsevier
NK cells play an important role in immune regulation and defense of infection, but their
characteristics in patients with decompensated cirrhosis and their relationship with liver …

Muscle-derived TRAIL negatively regulates myogenic differentiation

D Kim, N Singh, RJ Waldemer-Streyer, MS Yoon… - Experimental cell …, 2020 - Elsevier
TNF-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells,
although non-apoptotic functions have also been reported for this cytokine in various cell …