Prolonged versus intermittent β-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial …

Y Kondo, K Ota, H Imura, N Hara, N Shime - Journal of Intensive Care, 2020 - Springer
Background The prolonged β-lactam infusion strategy has emerged as the standard
treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess …

Comparing clinical outcomes of piperacillin-tazobactam administration and dosage strategies in critically ill adult patients: a systematic review and meta-analysis

S Fawaz, S Barton, S Nabhani-Gebara - BMC Infectious Diseases, 2020 - Springer
Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

Differential antibiotic dosing in critical care: survey on nurses' knowledge, perceptions and experience

S Fawaz, S Barton, L Whitney… - JAC-Antimicrobial …, 2020 - academic.oup.com
Background With the discovery of new antibiotics diminishing, optimizing the administration
of existing antibiotics has become a necessity. Critical care nurses play a crucial role in …

Benefits of prolonged infusion of beta-lactam antibiotics in patients with sepsis: personal perspectives

PI Rafailidis, ME Falagas - Expert Review of Anti-infective Therapy, 2020 - Taylor & Francis
Introduction In the current era of relatively scarce antibiotic production and significant levels
of antimicrobial resistance, optimization of pharmacokinetics and pharmacodynamics of …