Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
M Rigau, S Ostrouska, TS Fulford, DN Johnson… - Science, 2020 - science.org
INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …
The guidance receptor plexin D1 is a mechanosensor in endothelial cells
V Mehta, KL Pang, D Rozbesky, K Nather, A Keen… - Nature, 2020 - nature.com
Shear stress on arteries produced by blood flow is important for vascular development and
homeostasis but can also initiate atherosclerosis. Endothelial cells that line the vasculature …
homeostasis but can also initiate atherosclerosis. Endothelial cells that line the vasculature …
[HTML][HTML] Neutralization of SARS-CoV-2 by destruction of the prefusion spike
There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
The structure of human thyroglobulin
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for
growth, development and the control of metabolism in vertebrates,. Hormone synthesis from …
growth, development and the control of metabolism in vertebrates,. Hormone synthesis from …
Structural basis of teneurin-latrophilin interaction in repulsive guidance of migrating neurons
D Del Toro, MA Carrasquero-Ordaz, A Chu, T Ruff… - Cell, 2020 - cell.com
Teneurins are ancient metazoan cell adhesion receptors that control brain development and
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …
Glypicans shield the Wnt lipid moiety to enable signalling at a distance
A relatively small number of proteins have been suggested to act as morphogens—
signalling molecules that spread within tissues to organize tissue repair and the …
signalling molecules that spread within tissues to organize tissue repair and the …
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
K Suzuki, J Elegheert, I Song, H Sasakura, O Senkov… - Science, 2020 - science.org
INTRODUCTION Synapses are fundamental structural and functional units within neural
circuits, where they define the connectivity between neurons and provide avenues for …
circuits, where they define the connectivity between neurons and provide avenues for …
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer
A Stsiapanava, C Xu, M Brunati… - The EMBO …, 2020 - embopress.org
Assembly of extracellular filaments and matrices mediating fundamental biological
processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven …
processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven …
[HTML][HTML] Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics
The class BG protein-coupled receptor (GPCR) calcitonin receptor (CTR) is a drug target for
osteoporosis and diabetes. N-glycosylation of asparagine 130 in its extracellular domain …
osteoporosis and diabetes. N-glycosylation of asparagine 130 in its extracellular domain …
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or
MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We …
MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We …