Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that
manifest various motor and nonmotor symptoms. Although currently available therapies can …
manifest various motor and nonmotor symptoms. Although currently available therapies can …
Therapeutically significant microRNAs in primary and metastatic brain malignancies
Simple Summary The overall survival of brain cancer patients remains grim, with
conventional therapies such as chemotherapy and radiotherapy only providing marginal …
conventional therapies such as chemotherapy and radiotherapy only providing marginal …
Structure–Activity Relationship Study of a Potent α‐Thrombin Binding Aptamer Incorporating Hexitol Nucleotides
The replacement of one or more nucleotide residues in the potent α‐thrombin‐binding
aptamer NU172 with hexitol‐based nucleotides has been devised to study the effect of these …
aptamer NU172 with hexitol‐based nucleotides has been devised to study the effect of these …
Development of Novel Chemically-Modified Nucleic Acid Molecules for Efficient Inhibition of Human MAPT Gene Expression
The hyperphosphorylation of the microtubule-associated protein tau (MAPT) has been
implicated in various neurological diseases, including Alzheimer's disease. It has been …
implicated in various neurological diseases, including Alzheimer's disease. It has been …
Novel disulfide-bridged bioresponsive antisense oligonucleotide induces efficient splice modulation in muscle myotubes in vitro
Splice-modulating antisense therapy has shown tremendous potential in therapeutic
development in recent years with four FDA-approved antisense drugs since 2016. However …
development in recent years with four FDA-approved antisense drugs since 2016. However …
Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro
P Raguraman, T Wang, L Ma, PT Jørgensen… - International Journal of …, 2020 - mdpi.com
Alpha-l-Locked nucleic acid (α-l-LNA) is a stereoisomeric analogue of locked nucleic acid
(LNA), which possesses excellent biophysical properties and also exhibits high target …
(LNA), which possesses excellent biophysical properties and also exhibits high target …
Antisense oligonucleotide-mediated exon skipping strategies as the treatment for rare diseases
D Li - 2020 - researchportal.murdoch.edu.au
Antisense oligomer-mediated exon skipping is being developed as a strategy for
personalised treatment of genetic disorders through excising “in-frame” exons carrying small …
personalised treatment of genetic disorders through excising “in-frame” exons carrying small …