Drug studies on Rett syndrome: from bench to bedside
M Gomathi, S Padmapriya, V Balachandar - Journal of autism and …, 2020 - Springer
Drug studies on Rett syndrome (RTT) have drastically increased over the past few decades.
This review aims to provide master data on bench-to-bedside drug studies involving RTT. A …
This review aims to provide master data on bench-to-bedside drug studies involving RTT. A …
Compromised immune/inflammatory responses in Rett syndrome
A Pecorelli, C Cervellati, V Cordone, J Hayek… - Free Radical Biology …, 2020 - Elsevier
Mutations in X-linked gene methyl-CpG-binding protein 2 (MECP2), a key transcriptional
regulator, account for most cases of Rett syndrome (RTT), a devastating …
regulator, account for most cases of Rett syndrome (RTT), a devastating …
Dendrimer-mediated targeted delivery of rapamycin to tumor-associated macrophages improves systemic treatment of glioblastoma
Glioblastoma exhibits high mortality rates due to challenges with drug delivery to the brain
and into solid tumors. This two-pronged barrier necessitates high doses of systemic …
and into solid tumors. This two-pronged barrier necessitates high doses of systemic …
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration
Malignant gliomas are the most common and aggressive form of primary brain tumors, with a
median survival of 15–20 months for patients receiving maximal interventions. Advances in …
median survival of 15–20 months for patients receiving maximal interventions. Advances in …
Nanoparticle‐microglial interaction in the ischemic brain is modulated by injury duration and treatment
Cerebral ischemia is a major cause of death in both neonates and adults, and currently has
no cure. Nanotechnology represents one promising area of therapeutic development for …
no cure. Nanotechnology represents one promising area of therapeutic development for …
The role of microglia in ischemic preconditioning
A McDonough, JR Weinstein - Glia, 2020 - Wiley Online Library
Ischemic preconditioning (IPC) is an experimental phenomenon in which a brief ischemic
stimulus confers protection against a subsequent prolonged ischemic event. Initially thought …
stimulus confers protection against a subsequent prolonged ischemic event. Initially thought …
The role of microglia in neurodevelopmental disorders and their therapeutics
R Coomey, R Stowell, A Majewska… - Current topics in …, 2020 - ingentaconnect.com
The development of new therapeutics is critically dependent on an understanding of the
molecular pathways, the disruption of which results in neurological symptoms. Genetic and …
molecular pathways, the disruption of which results in neurological symptoms. Genetic and …
Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model
Background Neuroinflammation mediated by microglia plays a central role in the
pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics …
pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics …
[HTML][HTML] Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome
Background: Elevated glutamate production and release from glial cells is a common feature
of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for …
of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for …
Dendrimer-based targeted drug delivery
Targeted drug delivery (TDD) means delivering of drugs to a specific site like infected organ,
tissue or cell. TDD is important to improve therapeutic efficacy of the therapy and to reduce …
tissue or cell. TDD is important to improve therapeutic efficacy of the therapy and to reduce …