[HTML][HTML] The M-current works in tandem with the persistent sodium current to set the speed of locomotion
J Verneuil, C Brocard, V Trouplin, L Villard… - PLoS …, 2020 - journals.plos.org
The central pattern generator (CPG) for locomotion is a set of pacemaker neurons endowed
with inherent bursting driven by the persistent sodium current (I NaP). How they proceed to …
with inherent bursting driven by the persistent sodium current (I NaP). How they proceed to …
[HTML][HTML] The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function
SU Vay, LJ Flitsch, M Rabenstein, H Monière… - Journal of …, 2020 - Springer
Background Microglia are essential to maintain cell homeostasis in the healthy brain and
are activated after brain injury. Upon activation, microglia polarize towards different …
are activated after brain injury. Upon activation, microglia polarize towards different …
[HTML][HTML] Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels
Opening of large conductance calcium-activated and voltage-dependent potassium (BKCa)
channels hyperpolarizes plasma membranes of smooth muscle (SM) to cause vasodilation …
channels hyperpolarizes plasma membranes of smooth muscle (SM) to cause vasodilation …
The mechanisms shaping CA2 pyramidal neuron action potential bursting induced by muscarinic acetylcholine receptor activation
V Robert, L Therreau, MF Davatolhagh… - Journal of General …, 2020 - rupress.org
Recent studies have revealed that hippocampal area CA2 plays an important role in
hippocampal network function. Disruption of this region has been implicated in …
hippocampal network function. Disruption of this region has been implicated in …
In vivo attenuation of M-current suppression impairs consolidation of object recognition memory
A Kosenko, S Moftakhar, MA Wood… - Journal of …, 2020 - Soc Neuroscience
The M-current is a low voltage-activated potassium current generated by neuronal Kv7
channels. A prominent role of the M-current is to a create transient increase of neuronal …
channels. A prominent role of the M-current is to a create transient increase of neuronal …
RNA interference-mediated silencing of Kv7. 2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener
M Valdor, A Wagner, H Fischer, V Röhrs… - … of Pharmacological and …, 2020 - Elsevier
Introduction Development of agonistic analgesic drugs requires proof of selectivity in vivo
attainable by selective antagonists or several knockdown strategies. The Kv7. 2 potassium …
attainable by selective antagonists or several knockdown strategies. The Kv7. 2 potassium …
The role of vascular smooth muscle Kv7 channels in renal perfusion
F Stocker - 2020 - archiv.ub.uni-heidelberg.de
Vascular smooth muscle cell membranes contain potassium channels that by influencing
membrane potential importantly contribute to the regulation of arterial tone. The KCNQ gene …
membrane potential importantly contribute to the regulation of arterial tone. The KCNQ gene …
Removal of KCNQ2 from Parvalbumin-expressing Interneurons Improves Anti-Seizure Efficacy of Retigabine
Most anti-seizure drugs (ASDs) achieve their effects by suppressing neuronal excitability
through various drug targets. However, these drug targets are widely expressed in both …
through various drug targets. However, these drug targets are widely expressed in both …
A KCNQ2 variant causing Early Onset Epileptic Encephalopathy increases spontaneous network-driven activity and excitability of pyramidal cells in the layer II/III and …
N Biba, M Kurz, L Villard, M Milh, H Becq, L Aniksztejn - bioRxiv, 2020 - biorxiv.org
De novo variants in the KCNQ2 gene encoding the Kv7. 2 subunit of the voltage-gated
potassium Kv7/M channel are the main cause of Early Onset Epileptic Encephalopathy …
potassium Kv7/M channel are the main cause of Early Onset Epileptic Encephalopathy …
[PDF][PDF] Dynamic remodeling of the ionic basis of an intrinsic inhibitory response by the phospholipid PIP2
S Nicholls - 2020 - prism.ucalgary.ca
The excitability of an individual neuron can be directly related to the different types of
potassium channels it expresses. Potassium channels that are activated by either calcium or …
potassium channels it expresses. Potassium channels that are activated by either calcium or …