A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

[HTML][HTML] Evolutionary perspectives on the developing skeleton and implications for lifelong health

AE Kralick, BS Zemel - Frontiers in endocrinology, 2020 - frontiersin.org
Osteoporosis is a significant cause of morbidity and mortality in contemporary populations.
This common disease of aging results from a state of bone fragility that occurs with low bone …

[HTML][HTML] Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

BH Mullin, J Tickner, K Zhu, J Kenny, S Mullin… - Genome biology, 2020 - Springer
Background Osteoporosis is a complex disease with a strong genetic contribution. A recently
published genome-wide association study (GWAS) for estimated bone mineral density …

Wnt modulation in bone healing

D Schupbach, M Comeau-Gauthier, E Harvey, G Merle - Bone, 2020 - Elsevier
Genetic studies have been instrumental in the field of orthopaedics for finding tools to
improve the standard management of fractures and delayed unions. The Wnt signaling …

Clinical phenotype and relevance of LRP5 and LRP6 variants in patients with early‐onset osteoporosis (EOOP)

J Stürznickel, T Rolvien, A Delsmann… - Journal of Bone and …, 2020 - academic.oup.com
Reduced bone mineral density (BMD; ie, Z‐score≤− 2.0) occurring at a young age (ie,
premenopausal women and men< 50 years) in the absence of secondary osteoporosis is …

Swimming as Treatment for Osteoporosis: A Systematic Review and Meta‐analysis

Y Su, Z Chen, W Xie - BioMed research international, 2020 - Wiley Online Library
Osteoporosis is a chronic disease that seriously affects human health and quality of life. This
study is aimed at determining whether swimming had an effect on the bone mineral density …

[HTML][HTML] Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases

TC Martin, M Šimurina, M Ząbczyńska… - Molecular & cellular …, 2020 - ASBMB
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases,
associated with lymphocyte infiltration and the production of thyroid autoantibodies, like …

Lrp5 mutant and Crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of …

JW Bek, C Shochat, A De Clercq… - Journal of Bone and …, 2020 - academic.oup.com
Genomewide association studies (GWAS) have improved our understanding of the genetic
architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute …

[HTML][HTML] Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens

J Huang, XF Tong, ZW Yu, YP Hu, L Zhang, Y Liu… - Poultry science, 2020 - Elsevier
Caged layer osteoporosis (CLO) is a common bone metabolism diseases and poses a great
threat to the production of laying hens. So far, there is no effective nutrition intervention to …

Prioritization of genes relevant to bone fragility through the unbiased integration of aging mouse bone transcriptomics and human GWAS analyses

S Kaya, CA Schurman, NS Dole… - Journal of Bone and …, 2020 - academic.oup.com
Identifying new genetic determinants of bone mineral density (BMD) and fracture promises
to yield improved diagnostics and therapies for bone fragility. However, prioritizing …