A road map for understanding molecular and genetic determinants of osteoporosis
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
[HTML][HTML] Evolutionary perspectives on the developing skeleton and implications for lifelong health
AE Kralick, BS Zemel - Frontiers in endocrinology, 2020 - frontiersin.org
Osteoporosis is a significant cause of morbidity and mortality in contemporary populations.
This common disease of aging results from a state of bone fragility that occurs with low bone …
This common disease of aging results from a state of bone fragility that occurs with low bone …
[HTML][HTML] Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
BH Mullin, J Tickner, K Zhu, J Kenny, S Mullin… - Genome biology, 2020 - Springer
Background Osteoporosis is a complex disease with a strong genetic contribution. A recently
published genome-wide association study (GWAS) for estimated bone mineral density …
published genome-wide association study (GWAS) for estimated bone mineral density …
Wnt modulation in bone healing
Genetic studies have been instrumental in the field of orthopaedics for finding tools to
improve the standard management of fractures and delayed unions. The Wnt signaling …
improve the standard management of fractures and delayed unions. The Wnt signaling …
Clinical phenotype and relevance of LRP5 and LRP6 variants in patients with early‐onset osteoporosis (EOOP)
J Stürznickel, T Rolvien, A Delsmann… - Journal of Bone and …, 2020 - academic.oup.com
Reduced bone mineral density (BMD; ie, Z‐score≤− 2.0) occurring at a young age (ie,
premenopausal women and men< 50 years) in the absence of secondary osteoporosis is …
premenopausal women and men< 50 years) in the absence of secondary osteoporosis is …
Swimming as Treatment for Osteoporosis: A Systematic Review and Meta‐analysis
Y Su, Z Chen, W Xie - BioMed research international, 2020 - Wiley Online Library
Osteoporosis is a chronic disease that seriously affects human health and quality of life. This
study is aimed at determining whether swimming had an effect on the bone mineral density …
study is aimed at determining whether swimming had an effect on the bone mineral density …
[HTML][HTML] Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases
TC Martin, M Šimurina, M Ząbczyńska… - Molecular & cellular …, 2020 - ASBMB
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases,
associated with lymphocyte infiltration and the production of thyroid autoantibodies, like …
associated with lymphocyte infiltration and the production of thyroid autoantibodies, like …
Lrp5 mutant and Crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of …
JW Bek, C Shochat, A De Clercq… - Journal of Bone and …, 2020 - academic.oup.com
Genomewide association studies (GWAS) have improved our understanding of the genetic
architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute …
architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute …
[HTML][HTML] Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens
J Huang, XF Tong, ZW Yu, YP Hu, L Zhang, Y Liu… - Poultry science, 2020 - Elsevier
Caged layer osteoporosis (CLO) is a common bone metabolism diseases and poses a great
threat to the production of laying hens. So far, there is no effective nutrition intervention to …
threat to the production of laying hens. So far, there is no effective nutrition intervention to …
Prioritization of genes relevant to bone fragility through the unbiased integration of aging mouse bone transcriptomics and human GWAS analyses
Identifying new genetic determinants of bone mineral density (BMD) and fracture promises
to yield improved diagnostics and therapies for bone fragility. However, prioritizing …
to yield improved diagnostics and therapies for bone fragility. However, prioritizing …