Whilst the prevalence of obesity continues to increase at an alarming rate worldwide, the
personal and economic burden of obesity-related complications becomes ever more …

Abstract Purpose of Review This review provides an update on the role of gut hormones and
their interactions in the regulation of energy homeostasis, describes gut hormone …

Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and
type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1 receptor (GLP-1R) and …

Background Obesity is a major public health problem whose prevalence has been rapidly
increasing in the United States (US), and globally. It is one of the leading causes of …

25 years ago, the future of treating obesity and diabetes focused on end organs known to be
involved in energy balance and glucose regulation, including the brain, muscle, adipose …

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …

Oxyntomodulin (OXM) is an intestinal peptide hormone that activates both glucagon-like
peptide-1 (GLP-1) and glucagon (GCG) receptors. The natural peptide reduces body weight …

Obesity prevalence continues to increase globally, leading to ill-health and reduced life
expectancy in those affected and an urgent need for effective preventative and therapeutic …

Abstract Purpose of Review There is currently a steep rise in the global prevalence of
obesity. Pharmaceutical therapy is a valuable component of conservative obesity therapy …

OBJECTIVE: New-onset diabetes is an important sequela of acute pancreatitis, but there are
no biomarkers to differentiate it from the much more common type 2 diabetes. The objective …