Keratin intermediate filament proteins are major cytoskeletal components of the mammalian
simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt epithelial …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Cisplatin (CP) is one of the most active medications in cancer treatment and has some
adverse effects such as hepatotoxicity and nephrotoxicity. The present research was …

It is estimated that 10% of the worldwide population suffers from chronic kidney disease
(CKD) with a rising tendency. Patients with CKD have limited treatment options and novel …

Female sex protects against development of acute kidney injury (AKI). While sex hormones
may be involved in protection, the role of differential gene expression is unknown. We …

Creatinine and proteinuria are used to monitor kidney transplant patients. However, renal
biopsies are needed to diagnose renal graft rejection. Here, we assessed whether the …

The basic functional unit in a kidney is the nephron, which is a long and morphologically
segmented tubule. The nephron begins with a cluster of capillaries called glomerulus …

Summary We introduce the Transcriptome State Perturbation Generator (TSPG) as a novel
deep-learning method to identify changes in genomic expression that occur between tissue …

IgA nephropathy (IgAN) is one of the most diffuse glomerulonephrites worldwide, and many
issues still remain regarding our understanding of its pathogenesis. The disease is …

Renal interstitial fibrosis is a key factor in the development of chronic renal diseases,
possibly leading to uremia. The present study conducted aimed to assess the hypothesis …