Substantial evidence from various studies suggests a preeminent role for early adverse
experiences in the development of psychopathology. The most recent studies reviewed here …

Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …

Background Childhood maltreatment has been associated with significant impairment in
social, emotional and behavioural functioning later in life. Nevertheless, some individuals …

Suicide is a global health issue accounting for at least 800,000 deaths per annum.
Numerous models have been proposed that differ in their emphasis on the role of …

Fueling the rapid growth in our understanding of how stress influences cognition, the
number of studies examining the effects of stress on various cognitive processes has grown …

The stress sensitization model was developed to explain the mechanism through which the
relationship between stress and affective disorder onsets changes across the course of the …

Suicide is a leading cause of mortality worldwide. Dysregulated hypothalamic-pituitary-
adrenal (HPA) axis activity, as measured by cortisol levels, has been identified as 1 potential …

Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of
bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on …

Pregnancy is a period of major transformations in a woman's life; increased stress, and
mood and sleep disorders are frequent. This review evaluates mindfulness interventions …

Background: Childhood trauma is an important early social risk factor for the development of
the major depressive disorder (MDD). Both childhood trauma and depression are …