The treatment landscape of metastatic renal cell carcinoma (RCC) has been revolutionized
over the past two decades, bringing forth an era in which more than a dozen therapeutic …

Angiogenesis, the formation of new blood vessels from preexisting one, represents a critical
process for oxygen and nutrient supply to proliferating cells, therefore promoting tumor …

A number of novel anticancer drugs have been developed in recent years. However, the
mortality of cancer patients remains high because of the emergence of drug resistance. It …

Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors
derived from gluconeogenic tissues including liver and kidney, yet the definitive regulatory …

Simple Summary Cancer cells change their metabolism to support a chaotic and
uncontrolled growth. In addition to meeting the metabolic needs of the cell, these changes in …

Acquired resistance and intrinsic to sorafenib therapy represents a major hurdle in
improving the management of advanced hepatocellular carcinoma (HCC), which has been …

The engraftment of human tumor tissues into immunodeficient host mice to generate patient-
derived xenograft (PDX) models has become increasingly utilized for many types of cancers …

Neurofibromatosis Type 1 (NF1)-related Malignant Peripheral Nerve Sheath Tumors
(MPNST) are highly resistant sarcomas that account for significant mortality. The …

Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell
carcinoma (ccRCC), but novel therapeutic strategies are needed. The angiopoietin/Tie2 and …

To summarize the epigenetics in renal cell carcinoma (RCC) and discuss the potential use
of epigenetic modifiers as RCC biomarkers and treatments. Pertinent articles available on …