Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

A great effort of research has been devoted in the last few years to developing new anti-HBV
therapies of finite duration that also provide effective sustained control of virus replication …

In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …

Immune tolerance is one of the leading causes of chemotherapy resistance in carcinoma
cases. Studies have shown that programmed cell death ligand-1 (PD-L1), an inhibitory …

Liver transplantation is the ideal treatment approach for a variety of end-stage liver diseases.
However, life-long, systemic immunosuppressive treatment after transplantation is required …

The liver is a critical organ in controlling immune tolerance. In particular, it is now clear that
targeting antigens for presentation by antigen presenting cells in the liver can induce …

Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …

Objective Hepatic stellate cells (HSCs) are the important players in liver cirrhosis and liver
cancer. They also act as critical mediators of immunosuppression in hepatocellular …