The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …

Worldwide, Alzheimer's disease (AD) is the most common age-related neurodegenerative
disease and is characterized by unique pathological hallmarks in the brain, including …

Individual Alzheimer's disease (AD) patients have been shown to have structurally distinct
amyloid-β (Aβ) aggregates, including fibrils, in their brain. These findings suggest the …

Reports on phase separation and amyloid formation for multiple proteins and aggregation-
prone peptides are recurrently used to explore the molecular mechanisms associated with …

In amyloid fibril elongation, soluble growth substrate binds to the fibril-end and converts into
the fibril conformation. This process is targeted by inhibitors that block fibril-ends. Here, we …

The aggregation behavior of amyloid-β (Aβ) peptides remains unclarified despite the fact
that it is closely related to the pathogenic mechanism of Alzheimer's disease. Aβ peptides …

Amyloid fibril formation is central to the etiology of a wide range of serious human diseases,
such as Alzheimer's disease and prion diseases. Despite an ever growing collection of …

Alzheimer's disease (AD) is a serious neuropathology related to the misfolded assembly
state of amyloid-beta (Aβ40 and Aβ42) peptides. It has been demonstrated that protein post …

Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of
the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self …

An increasing number of human disorders has been identified as associated to or directly
caused by aberrant protein aggregation and especially amyloid fibril formation. In this …