Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
Cellular and mitochondrial mechanisms of atrial fibrillation
The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …
The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society comprehensive guidelines for the management of atrial fibrillation
JG Andrade, M Aguilar, C Atzema, A Bell… - Canadian Journal of …, 2020 - Elsevier
Abstract The Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines
program was developed to aid clinicians in the management of these complex patients, as …
program was developed to aid clinicians in the management of these complex patients, as …
Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation
Rationale: Postoperative atrial fibrillation (POAF) is a common and troublesome
complication of cardiac surgery. POAF is generally believed to occur when postoperative …
complication of cardiac surgery. POAF is generally believed to occur when postoperative …
Animal models of atrial fibrillation
D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
Loss of SPEG inhibitory phosphorylation of ryanodine receptor type-2 promotes atrial fibrillation
HM Campbell, AP Quick, I Abu-Taha, DY Chiang… - Circulation, 2020 - Am Heart Assoc
Background: Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing
S Lebek, K Pichler, K Reuthner, M Trum… - Circulation …, 2020 - Am Heart Assoc
Rationale: Sleep-disordered breathing (SDB) is frequently associated with atrial
arrhythmias. Increased CaMKII (Ca/calmodulin-dependent protein kinase II) activity has …
arrhythmias. Increased CaMKII (Ca/calmodulin-dependent protein kinase II) activity has …
Integrin β1D deficiency–mediated RyR2 dysfunction contributes to catecholamine-sensitive ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary heart
disease characterized by fatty infiltration, life-threatening arrhythmias, and increased risk of …
disease characterized by fatty infiltration, life-threatening arrhythmias, and increased risk of …
Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure
P Connell, TA Word, XHT Wehrens - Expert opinion on therapeutic …, 2020 - Taylor & Francis
ABSTRACT Introduction: Type-2 ryanodine receptor (RyR2) located on the sarcoplasmic
reticulum initiate systolic Ca2+ transients within cardiomyocytes. Proper functioning of RyR2 …
reticulum initiate systolic Ca2+ transients within cardiomyocytes. Proper functioning of RyR2 …