Objectives To systematically review the efficacy and safety of anti-inflammatory agents for
patients with major depressive disorders. Methods We searched the literature to identify …

BackgroundMood disorders, ie major depressive disorder (MDD) and bipolar disorders, are
leading sources of disability worldwide. Currently available treatments do not yield …

Background Several small studies suggest that the adjunctive use of anti-inflammatory
agents might improve depressive symptoms in bipolar disorder. However, there are few well …

Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …

Background Studies have suggested that chronic social stress specifically downregulates
endothelial tight junction protein expression in the nucleus accumbens (NAc), thus …

Objective The goal of this study was to reduce treatment resistance and enhance
antidepressant response in patients with treatment-resistant bipolar depression (TRBDD) by …

Accumulating evidence suggests that neuroinflammation is involved in bipolar disorder (BD)
pathogenesis. The tumor necrosis factor-alpha (TNF-α) antagonist infliximab was recently …

Introduction Accumulating evidence indicates the effectiveness of cryogenic temperature
interventions in rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, multiple sclerosis …

Background Available evidence suggests that adjunctive treatment with immunomodulatory
medications may be effective in the treatment of major depressive disorder (MDD). A pilot …

In people with depression, immune dysfunctions have been linked with treatment non-
response, but examinations of psychological therapy outcomes, particularly longitudinal …