Updated overview of the SEER-Medicare data: enhanced content and applications

L Enewold, H Parsons, L Zhao, D Bott… - JNCI …, 2020 - academic.oup.com
Abstract Background The National Cancer Institute's Surveillance, Epidemiology, and End
Results (SEER)-Medicare–linked database was first created almost 30 years ago. Over time …

[HTML][HTML] The influence of radiation on bone and bone cells—differential effects on osteoclasts and osteoblasts

AJ Donaubauer, L Deloch, I Becker, R Fietkau… - International Journal of …, 2020 - mdpi.com
The bone is a complex organ that is dependent on a tight regulation between bone
formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes …

Pelvic insufficiency fractures after external beam radiation therapy for gynecologic cancers: a meta-analysis and meta-regression of 3929 patients

LG Sapienza, MP Salcedo, MS Ning, A Jhingran… - International Journal of …, 2020 - Elsevier
Purpose To estimate the overall rate, symptomatic proportion, and most common sites of
pelvic insufficiency fracture (PIF) after external beam radiation therapy for gynecologic …

[HTML][HTML] Fat and bone: the multiperspective analysis of a close relationship

MPA Gómez, CA Benavent, P Simoni… - … imaging in medicine …, 2020 - ncbi.nlm.nih.gov
The study of bone has for many years been focused on the study of its mineralized
component, and one of the main objects of study as radiology developed as a medical …

Radiation-induced insufficiency fractures after pelvic irradiation for gynecologic malignancies: a systematic review

N Razavian, A Laucis, Y Sun, DE Spratt, D Owen… - International Journal of …, 2020 - Elsevier
Purpose To identify and define the incidence, risk factors, clinical characteristics, and
treatment approaches to pelvic insufficiency fractures (PIFs) that develop as a consequence …

Pelvic fractures and changes in bone mineral density after radiotherapy for cervical, endometrial, and vaginal cancer: a prospective study of 239 women

MP Salcedo, AK Sood, A Jhingran, PJ Eifel, AH Klopp… - Cancer, 2020 - Wiley Online Library
Background Advances in radiotherapy (RT) have led to improved oncologic outcomes for
women with gynecologic cancers; however, the long‐term effects and survivorship …

[HTML][HTML] Radiation-induced changes to bone composition extend beyond periosteal bone

GS Mandair, ME Oest, KA Mann, MD Morris… - Bone Reports, 2020 - Elsevier
Background Cancer patients receiving radiotherapy for soft tissue sarcomas are often at risk
of post-irradiation (post-RTx) bone fragility fractures, but our understanding of factors …

Risk of pelvic fracture with radiation therapy in older patients

LK Vitzthum, H Park, K Zakeri, ES Heide… - International Journal of …, 2020 - Elsevier
Purpose Older patients undergoing radiation therapy (RT) for pelvic malignancies are at
increased risk for pelvic fracture, which is associated with significant morbidity and mortality …

Challenges and advances in cervix cancer treatment in elder women

M Kissel, A Rambeau, S Achkar, F Lecuru… - Cancer treatment …, 2020 - Elsevier
With population ageing, cancer treatments in elder patients is becoming a true public health
care issue. There is an authentic dilemma between patient's frailty, residual life expectancy …

Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice

FC Ko, MM Kobelski, W Zhang… - Journal of Bone and …, 2020 - academic.oup.com
Bone marrow stromal cells (BMSCs) are multipotent cells that differentiate into cells of the
osteogenic and adipogenic lineage. A striking inverse relationship between bone marrow …