Creatine metabolism: energy homeostasis, immunity and cancer biology

L Kazak, P Cohen - Nature Reviews Endocrinology, 2020 - nature.com
Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …

White adipose tissue mitochondrial metabolism in health and in obesity

S Heinonen, R Jokinen, A Rissanen… - Obesity …, 2020 - Wiley Online Library
White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐
body energy status and metabolism; it not only stores excess energy but also secretes …

Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity

V Cifarelli, SC Beeman, GI Smith… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Data from studies conducted in rodent models have shown that decreased
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …

[HTML][HTML] New role for ceramide in hypoxia and insulin resistance

QS Xia, FE Lu, F Wu, ZY Huang, H Dong… - World Journal of …, 2020 - ncbi.nlm.nih.gov
Ceramides are significant metabolic products of sphingolipids in lipid metabolism and are
associated with insulin resistance and hepatic steatosis. In chronic inflammatory …

[HTML][HTML] Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

M Riopel, JS Moon, GK Bandyopadhyay, S You… - Molecular …, 2020 - Elsevier
Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD)
proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans …

Mitochondrial energy-regulating effect of atractyloside inhibits hepatocellular steatosis through the activation of autophagy

P Zhang, L Li, H Sun, Y Zhang, G Zhang… - Frontiers in …, 2020 - frontiersin.org
Background and Aim Atractyloside (ATR), a mitochondrial uncoupler, is known for its specific
inhibition of mitochondrial oxidative phosphorylation. Previous studies have reported that …

Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function

CR Kliment, JMK Nguyen, MJ Kaltreider, YW Lu… - bioRxiv, 2020 - biorxiv.org
Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in
chronic obstructive lung disease (COPD). COPD is the 4th leading cause of death in the US …

IF1 connects obesity and insulin resistance through mitochondrial reprogramming in association with ANT2

Y Wang, Y Guan, J Zhang, X Cao, S Shen, G Zhong… - bioRxiv, 2020 - biorxiv.org
Abstract IF1 (ATPIF1) is a nuclear DNA-encoded protein with an activity in the inhibition of
catalytic activity of F1Fo-ATP synthase (ATPase), an enzyme for ATP synthesis in …