Creatine metabolism: energy homeostasis, immunity and cancer biology
L Kazak, P Cohen - Nature Reviews Endocrinology, 2020 - nature.com
Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …
White adipose tissue mitochondrial metabolism in health and in obesity
S Heinonen, R Jokinen, A Rissanen… - Obesity …, 2020 - Wiley Online Library
White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐
body energy status and metabolism; it not only stores excess energy but also secretes …
body energy status and metabolism; it not only stores excess energy but also secretes …
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity
BACKGROUND Data from studies conducted in rodent models have shown that decreased
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …
[HTML][HTML] New role for ceramide in hypoxia and insulin resistance
QS Xia, FE Lu, F Wu, ZY Huang, H Dong… - World Journal of …, 2020 - ncbi.nlm.nih.gov
Ceramides are significant metabolic products of sphingolipids in lipid metabolism and are
associated with insulin resistance and hepatic steatosis. In chronic inflammatory …
associated with insulin resistance and hepatic steatosis. In chronic inflammatory …
[HTML][HTML] Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism
M Riopel, JS Moon, GK Bandyopadhyay, S You… - Molecular …, 2020 - Elsevier
Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD)
proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans …
proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans …
Mitochondrial energy-regulating effect of atractyloside inhibits hepatocellular steatosis through the activation of autophagy
P Zhang, L Li, H Sun, Y Zhang, G Zhang… - Frontiers in …, 2020 - frontiersin.org
Background and Aim Atractyloside (ATR), a mitochondrial uncoupler, is known for its specific
inhibition of mitochondrial oxidative phosphorylation. Previous studies have reported that …
inhibition of mitochondrial oxidative phosphorylation. Previous studies have reported that …
Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function
CR Kliment, JMK Nguyen, MJ Kaltreider, YW Lu… - bioRxiv, 2020 - biorxiv.org
Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in
chronic obstructive lung disease (COPD). COPD is the 4th leading cause of death in the US …
chronic obstructive lung disease (COPD). COPD is the 4th leading cause of death in the US …
IF1 connects obesity and insulin resistance through mitochondrial reprogramming in association with ANT2
Y Wang, Y Guan, J Zhang, X Cao, S Shen, G Zhong… - bioRxiv, 2020 - biorxiv.org
Abstract IF1 (ATPIF1) is a nuclear DNA-encoded protein with an activity in the inhibition of
catalytic activity of F1Fo-ATP synthase (ATPase), an enzyme for ATP synthesis in …
catalytic activity of F1Fo-ATP synthase (ATPase), an enzyme for ATP synthesis in …