Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination, and related clinical implications

E Perucca, M Bialer - CNS drugs, 2020 - Springer
This article provides a critical appraisal of the available evidence concerning clinical
exposure to orally administered cannabidiol (CBD), with special reference to factors …

Molecular targets of cannabidiol in experimental models of neurological disease

S Silvestro, G Schepici, P Bramanti, E Mazzon - Molecules, 2020 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …

Can we treat neuroinflammation in Alzheimer's disease?

S Sánchez-Sarasúa, I Fernández-Pérez… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD), considered the most common type of dementia, is characterized
by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In …

Effects of cannabidiol and delta-9-tetrahydrocannabinol on emotion, cognition, and attention: a double-blind, placebo-controlled, randomized experimental trial in …

T Woelfl, C Rohleder, JK Mueller, B Lange… - Frontiers in …, 2020 - frontiersin.org
The two main phytocannabinoids—delta-9-tetrahydrocannabinol (THC) and cannabidiol
(CBD)—have been extensively studied, and it has been shown that THC can induce …

Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats

O Sadowska, M Baranowska-Kuczko… - International Journal of …, 2020 - mdpi.com
Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery),
anti-proliferative and anti-inflammatory properties. The aim of our study was to examine the …

Grinding and fractionation during distillation alter hemp essential oil profile and its antimicrobial activity

VD Zheljazkov, V Sikora, IB Semerdjieva, M Kačániová… - Molecules, 2020 - mdpi.com
The hypothesis of this study was that we can modify the essential oil (EO) profile of hemp
(Cannabis sativa L.) and obtain fractions with differential composition and antimicrobial …

Cannabis and canabidinoids on the inflammatory bowel diseases: going beyond misuse

ACA Carvalho, GA Souza, SV Marqui… - International Journal of …, 2020 - mdpi.com
Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent
gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn's disease (CD) …

Feline cognitive dysfunction as a model for Alzheimer's disease in the research of CBD as a potential treatment—a narrative review

L Zadik-Weiss, S Ritter, V Hermush, N Asher… - Journal of Cannabis …, 2020 - Springer
With the improvement in modern medicine, the world's human and feline (Felis catus, the
domestic cat) population is aging. As the population grows older, there is an increase of age …

Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?

C Viegas Jr, CAM Fraga, ME Sousa… - Frontiers in …, 2020 - frontiersin.org
Central Nervous System (CNS) disorders affect millions of people worldwide (Feigin et al.,
2019). Despite their growing impact on health systems and the urgent need for new, safer …

The positive and negative cardiovascular effects of cannabis

M Adamson, B Di Giovanni… - Expert Review of …, 2020 - Taylor & Francis
Introduction The use of cannabis and its derivatives have increased steadily over the past
few decades, prompting patients and clinicians to increasingly inquire about its health …