Recent update on basic mechanisms of spinal cord injury

SA Quadri, M Farooqui, A Ikram, A Zafar, MA Khan… - Neurosurgical …, 2020 - Springer
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury

GJ Duncan, SB Manesh, BJ Hilton, P Assinck… - Glia, 2020 - Wiley Online Library
Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

Schwann cell-like cells: origin and usability for repair and regeneration of the peripheral and central nervous system

A Hopf, DJ Schaefer, DF Kalbermatten, R Guzman… - Cells, 2020 - mdpi.com
Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor
and requires a surgical procedure. Especially for longer gaps (> 3 mm), end-to-end suturing …

[HTML][HTML] Novel innovations in cell and gene therapies for spinal cord injury

MM Zavvarian, A Toossi, M Khazaei, J Hong… - …, 2020 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) leads to chronic and multifaceted disability, which severely impacts
the physical and mental health as well as the socio-economic status of affected individuals …

Behavioral testing in animal models of spinal cord injury

K Fouad, C Ng, DM Basso - Experimental neurology, 2020 - Elsevier
This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored
Spinal Cord Injury Training Program at Ohio State University. We discuss the advantages …

Regenerative medicine for spinal cord injury: focus on stem cells and biomaterials

S Papa, F Pizzetti, G Perale… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Spinal cord injury (SCI) is a dramatic medical pathology consequence of a
trauma (primary injury). However, most of the post-traumatic degeneration of the tissue is …

[HTML][HTML] Transplantation of skin precursor-derived schwann cells yields better locomotor outcomes and reduces bladder pathology in rats with chronic spinal cord …

P Assinck, JS Sparling, S Dworski, GJ Duncan, DL Wu… - Stem Cell Reports, 2020 - cell.com
Cell transplantation for spinal cord injury (SCI) has largely been studied in sub-acute
settings within 1–2 weeks of injury. In contrast, here we transplanted skin-derived precursors …