Long noncoding RNAs in cancer: from discovery to therapeutic targets

R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …

[HTML][HTML] Exosomal long non-coding RNAs in lung diseases

C Poulet, MS Njock, C Moermans, E Louis… - International journal of …, 2020 - mdpi.com
Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their
secretion within exosomes are a window that could further explain the regulation, the …

[HTML][HTML] Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression

X Zang, J Gu, J Zhang, H Shi, S Hou, X Xu… - Cell death & …, 2020 - nature.com
Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …

[HTML][HTML] The Tug1 lncRNA locus is essential for male fertility

JP Lewandowski, G Dumbović, AR Watson, T Hwang… - Genome biology, 2020 - Springer
Abstract Background Several long noncoding RNAs (lncRNAs) have been shown to function
as components of molecular machines that play fundamental roles in biology. While the …

LncRNA TUG1 mediates ischemic myocardial injury by targeting miR-132-3p/HDAC3 axis

Q Su, Y Liu, XW Lv, RX Dai… - American Journal of …, 2020 - journals.physiology.org
Increased production of reactive oxygen species (ROS) significantly contributed to the
pathogenesis of acute myocardial infarction (AMI). Recent studies suggest that hypoxia …

Pathophysiological functions of the lncRNA TUG1

C Guo, Y Qi, J Qu, L Gai, Y Shi… - Current pharmaceutical …, 2020 - ingentaconnect.com
Background: Long non-coding RNAs (lncRNAs) with little or no coding capacity are
associated with a plethora of cellular functions, participating in various biological processes …

Long non-coding RNA in lung cancer

Z Chen, T Lei, X Chen, J Gu, J Huang, B Lu, Z Wang - Clinica chimica acta, 2020 - Elsevier
Lung cancer is the leading cause of cancer-related death worldwide. Owing to the difficulty
in early diagnosis and the lack of effective treatment strategies, the 5-year survival rates for …

[HTML][HTML] New insights into long non-coding RNAs in non-small cell lung cancer

R Ye, R Tang, S Gan, R Li, Y Cheng, L Guo… - Biomedicine & …, 2020 - Elsevier
Lung cancer is a malignant tumor that seriously threatens human life and health. Non-small
cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases, and its global 5-year …

[HTML][HTML] Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics?

S Baliou, AM Kyriakopoulos… - International …, 2020 - spandidos-publications.com
For one century, taurine is considered as an end product of sulfur metabolism. In this review,
we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 …

[HTML][HTML] Deciphering the mounting complexity of the p53 regulatory network in correlation to long non-coding RNAs (lncRNAs) in ovarian cancer

S Pal, M Garg, AK Pandey - Cells, 2020 - mdpi.com
Amongst the various gynecological malignancies affecting female health globally, ovarian
cancer is one of the predominant and lethal among all. The identification and functional …