Lipopolysaccharide recognition in the crossroads of TLR4 and caspase-4/11 mediated inflammatory pathways

A Zamyatina, H Heine - Frontiers in Immunology, 2020 - frontiersin.org
The innate immune response to lipopolysaccharide is essential for host defense against
Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is …

Roles of interactions between toll-like receptors and their endogenous ligands in the pathogenesis of systemic juvenile idiopathic arthritis and adult-onset still's …

JY Jung, JW Kim, CH Suh, HA Kim - Frontiers in Immunology, 2020 - frontiersin.org
Systemic juvenile idiopathic arthritis (JIA) and adult-onset Still's disease (AOSD) are
systemic inflammatory disorders that manifest as high-spiking fever, joint pain, evanescent …

[HTML][HTML] Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages

GY Kim, H Jeong, HY Yoon, HM Yoo, JY Lee… - BMB …, 2020 - ncbi.nlm.nih.gov
Suppressors of cytokine signaling (SOCS) exhibit diverse anti-inflammatory effects. Since
ROS acts as a critical mediator of inflammation, we have investigated the anti-inflammatory …

MCPIP1 RNase and its multifaceted role

R Musson, W Szukała, J Jura - International Journal of Molecular …, 2020 - mdpi.com
Inflammation is an organism's physiological response to harmful septic and aseptic stimuli.
This process begins locally through the influx of immune system cells to the damaged tissue …

A polysaccharide extracted from alfalfa activates splenic B cells by TLR4 and acts primarily via the MAPK/p38 pathway

Y Xie, L Wang, H Sun, Q Shang, Y Wang, G Zhang… - Food & function, 2020 - pubs.rsc.org
Alfalfa polysaccharide (APS) has been proposed to exhibit growth-promoting and immune-
enhancing bodily functions in vivo. However, little is known about its downstream …

How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?

R Xu, Y Li, Y Liu, J Qu, W Cao, E Zhang, J He… - Protein & Cell, 2020 - academic.oup.com
Cytokines are secreted by various cell types and act as critical mediators in many
physiological processes, including immune response and tumor progression. Cytokines …

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro

MB Ahmed, SU Islam, YS Lee - Animal cells and systems, 2020 - Taylor & Francis
The current investigation was carried out to analyze the correlation of bacterial
lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing …

Resistance genes and resistance protein function

DA Jones - Molecular Plant Pathology, 2020 - taylorfrancis.com
Despite the discovery of resistance genes (R genes) early in the twentieth century and of the
host-pathogen gene-for-gene relationship before the middle of the twentieth century, most …

Lipoproteins in Staphylococcus aureus infections

M Mohammad - 2020 - gupea.ub.gu.se
Staphylococcus aureus (S. aureus) infections remain a major challenge for the healthcare
system, and new treatment options are highly demanded. S. aureus is a pathogenic …

mRNAs of Genes of Toll-Like Receptors are Expressed in Human Fetal Eye Tissues

OV Burmenskaya, RA Poltavtseva… - Russian Journal of …, 2020 - Springer
The expression of mRNA genes of Toll-like receptors (TLRs) 2, 4, 7, 9 in the retina, lens, and
vitreous body of the eye of 13-, 17-, and 19-week fetuses is shown. The results of this work …