Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …

Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by
rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to …

Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that
plays a critical role in liver function and disease. To better understand this role, we …

The liver is the largest organ in the human body and is prone for cancer metastasis.
Although the metastatic pattern can differ depending on the cancer type, the liver is the …

The liver is a frontline immune tissue that plays a major role in the detection, capture and
clearance of pathogens and foreign antigens entering the bloodstream, especially from the …

The oncogene yes-associated protein (YAP) controls liver tumor initiation and progression
via cell extrinsic functions by creating a tumor-supporting environment in conjunction with …

(1) Background: Platelets were postulated to constitute the trigger of liver regeneration. The
aim of this study was to dissect the cellular interactions between the various liver cells …

Cirrhosis, a late form of liver disease, is characterized by extensive scarring due to
exacerbated secretion of extracellular matrix proteins by myofibroblasts that develop during …

Background Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident
macrophages) form the body's most effective scavenger cell system for the removal of …