Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

The tumor microenvironment (TME) is a complex environment where cancer cells reside and
interact with different types of cells, secreted factors, and the extracellular matrix …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Significant advances have been made towards understanding the role of immune cell-tumor
interplay in either suppressing or promoting tumor growth, progression, and recurrence …

Abstract Purpose of Review Senescent cells are now known to accumulate in multiple
tissues with aging and through their inflammation (the senescence-associated secretory …

Cellular senescence is traditionally considered as stable cell cycle arrest state with other
phenotypic alterations including the production of an array of cytokines and growth factors …

Cellular senescence is a state of stable growth arrest that acts as a tumor suppressive
mechanism. Genotoxic agents exert their anti-cancer functions partly by inducing cancer …

Cellular senescence is a stress response of stable growth arrest mediated by the CDK
inhibitors p16 and p21 which acts as a potent barrier to tumorigenesis. Senescent cells are …

Today, it is a time when we are facing immeasurable challenges as a global population. In
such times, it is commendable that scientific inquiry, medical care, research, and …