Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …

Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into
the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal …

Osteogenesis is the process of new bone formation where transcription factors play an
important role in controlling cell proliferation and differentiation. Runt-related transcription …

Adipocyte differentiation is driven by waves of transcriptional regulators that reprogram the
enhancer landscape and change the wiring of the promoter interactome. Here, we use high …

Neural crest cells are a vertebrate-specific migratory, multipotent cell population that give
rise to a diverse array of cells and tissues during development. Cranial neural crest cells, in …

The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly
regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and …

During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated
during nuclear reformation in anaphase/telophase. Many aspects of the underlying …

ABSTRACT Runt‐related transcription factor‐2 (Runx2) is an essential transcription factor
for osteoblast differentiation. However, its functions after the commitment into osteoblasts are …

Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial
role in osteoporosis. Irisin, an exercise-induced muscle-dependent myokine, has been …