Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects
Bone as such displays an intrinsic regenerative potential following fracture; however, this
capacity is limited with large bone defects that cannot heal spontaneously. The management …
capacity is limited with large bone defects that cannot heal spontaneously. The management …
[HTML][HTML] The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing …
DCT né Betts, E Wehrle, GR Paul, GA Kuhn… - Scientific …, 2020 - ncbi.nlm.nih.gov
An improved understanding of how local mechanical stimuli guide the fracture healing
process has the potential to enhance clinical treatment of bone injury. Recent preclinical …
process has the potential to enhance clinical treatment of bone injury. Recent preclinical …
The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing model
DC Tourolle né Betts, E Wehrle, GR Paul, GA Kuhn… - Scientific reports, 2020 - nature.com
An improved understanding of how local mechanical stimuli guide the fracture healing
process has the potential to enhance clinical treatment of bone injury. Recent preclinical …
process has the potential to enhance clinical treatment of bone injury. Recent preclinical …
Effects of strontium-doped β-tricalcium scaffold on longitudinal nuclear factor-kappa beta and vascular endothelial growth factor receptor-2 promoter activities during …
M Tohidnezhad, Y Kubo, P Lichte, T Heigl… - International journal of …, 2020 - mdpi.com
It was hypothesized that strontium (Sr)-doped β-tricalcium phosphate (TCP)-based scaffolds
have a positive effect on the regeneration of large bone defects (LBD). Readouts in our mice …
have a positive effect on the regeneration of large bone defects (LBD). Readouts in our mice …
Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice
AC Scheuren, GA Kuhn, R Müller - PLoS One, 2020 - journals.plos.org
I n vivo micro-CT has already been used to monitor microstructural changes of bone in mice
of different ages and in models of age-related diseases such as osteoporosis. However, as …
of different ages and in models of age-related diseases such as osteoporosis. However, as …
Reducing variance in a mouse defect healing model: Real-time Finite Element Analysis allows homogenization of tissue scale strains
Mechanical loading allows both investigation into the mechano-regulation of fracture
healing as well as interventions to improve fracture-healing outcomes such as delayed …
healing as well as interventions to improve fracture-healing outcomes such as delayed …
Bone Biology, Modeling, Remodeling, and Mineralization
The bone is a composite structure comprised primarily of mineral (hydroxyapatite) and
organic matrix composed of collagen and non-collagenous proteins. Bone formation occurs …
organic matrix composed of collagen and non-collagenous proteins. Bone formation occurs …
Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur …
E Wehrle, DC Tourolle né Betts, GA Kuhn, E Floreani… - bioRxiv, 2020 - biorxiv.org
Thorough preclinical evaluation of functionalized biomaterials for treatment of large bone
defects is essential prior to clinical application. Using in vivo micro-computed tomography …
defects is essential prior to clinical application. Using in vivo micro-computed tomography …
Subject-specific mechanical loading of bones: Improved healing of mouse vertebral defects using adaptive loading regimes
Methods to repair bone defects arising from trauma, resection, or disease, continue to be
sought after. Cyclic mechanical loading is well established to influence bone (re) modelling …
sought after. Cyclic mechanical loading is well established to influence bone (re) modelling …