Adrenoleukodystrophy (ALD) is a rare X‐linked disease caused by a mutation of the
peroxisomal ABCD1 gene. This review summarizes our current understanding of the …

The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …

Axonal loss is the key pathological substrate of neurological disability in demyelinating
disorders, including multiple sclerosis (MS). However, the consequences of demyelination …

Adrenoleukodystrophy (ALD) is a rare X-linked disorder of peroxisomal oxidation due to
mutations in ABCD1. It is a progressive condition with a variable clinical spectrum that …

Adrenoleukodystrophy is a neurometabolic disorder caused by a defective peroxisomal
ABCD1 transporter of very long-chain fatty acids (VLCFAs). Its pathogenesis is incompletely …

Biotin is an essential cofactor for carboxylases that regulates the energy metabolism.
Recently, high‐dose pharmaceutical‐grade biotin (MD1003) was shown to improve clinical …

Summary X-linked adrenoleukodystrophy (X-ALD) is a rare, genetic disease in which
increased very long chain fatty acids (VLCFAs) in the central nervous system (CNS) cause …

The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …

X-linked adrenoleukodystrophy (ALD) caused by the ABCD1 mutation, is the most common
inherited peroxisomal disease. It is characterized by three phenotypes: inflammatory …