Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

The blood–brain barrier (BBB) tightly controls the molecular exchange between the brain
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

There is a growing body of clinical and experimental evidence that neurodegenerative
diseases and epileptogenesis after an acquired brain insult may share common etiological …

Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the
disease pathogenesis as well as the high demand to explore novel treatment strategies. In …

Previous studies demonstrated that the pathophysiological changes after temporal lobe
epilepsy (TLE) such as oxidative stress, inflammatory reaction contribute to cognitive defect …

Background Evidence suggests that amyloid β (Aβ) peptides play an important role in the
degeneration of neurons during the development of Alzheimer's disease (AD), the prevalent …

The use of animal models is fundamental to furthering our understanding of human disease
mechanisms, as well as identifying potential therapeutic targets. Diseases of ageing often …

In our previous publication, it was shown that growth hormone (GH) excess in acromegaly
affects the cell integrity of somatic cells through increased DNA damage throughout the body …

In last decade functional brain mapping has made significant strides through development of
advanced methods, culminating into revolutionary diagnostic imaging and therapeutic …