Recent advances in novel drug delivery systems and approaches for management of breast cancer: A comprehensive review

U Hani, M Rahamathulla, RA Osmani, HY Kumar… - Journal of Drug Delivery …, 2020 - Elsevier
Breast Cancer (BC) is a carcinoma of breast tissues, the major recurrent cancer in women
and also the foremost cause of death with approximate 5 million annual deaths worldwide …

Carboxymethyl fenugreek galactomannan-g-poly (N-isopropylacrylamide-co-N, N′-methylene-bis-acrylamide)-clay based pH/temperature-responsive …

H Bera, YF Abbasi, V Gajbhiye, KF Liew… - Materials Science and …, 2020 - Elsevier
The current study dealt with the synthesis and characterization of carboxymethyl fenugreek
galactomannang-g-poly (N-isopropylacrylamide-co-N, N′-methylene-bis-acrylamide) …

Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

JT Hou, B Wang, Y Zhang, B Cui, X Cao… - Chemical …, 2020 - pubs.rsc.org
We describe a colorimetric and fluorescent probe 3a to detect cellular peroxynitrite with high
selectivity and sensitivity. 3a was successfully applied in the bioimaging of exogenous and …

Modulating the delivery of 5-fluorouracil to human colon cancer cells using multifunctional arginine-coated manganese oxide nanocuboids with MRI properties

P Jain, K Patel, AK Jangid, A Guleria… - ACS Applied Bio …, 2020 - ACS Publications
5-Fluorouracil (5-FU) is one of the most prescribed drugs and the major component of
chemotherapy for the treatment of colorectal cancer. In this study, we have designed …

Curcumin reduced gold nanoparticles synergistically induces ROS mediated apoptosis in MCF-7 cancer cells

S Kondath, R Rajaram… - Inorganic and Nano …, 2020 - Taylor & Francis
Curcumin nanotechnologies have increased the therapeutic efficacy of curcumin by
enhancing its bio-availability. We have previously reported on the synthesis of stable …

Silver nanotriangles and chemotherapeutics synergistically induce apoptosis in glioma cells via a ROS-dependent mitochondrial pathway

H Yang, W Chen, J Ma, J Zhao, D Li… - International journal of …, 2020 - Taylor & Francis
Background The synergistic effect of nanomaterials and chemotherapeutics provides a
novel strategy for the treatment of tumors. Silver nanotriangles (AgNTs) exhibited some …

Injectable multicomponent biomimetic gel composed of inter-crosslinked dendrimeric and mesoporous silica nanoparticles exhibits highly tunable elasticity and dual …

J Wang, B Li, X Pu, X Wang, RC Cooper… - … applied materials & …, 2020 - ACS Publications
There is a growing need for cartilage defect grafts that are structurally adaptable to possess
multifaceted functions to promote bone regeneration, sustain medication efficacy, and …

[HTML][HTML] 5-Fluorouracil Loaded Biogenic and Albumin Capped Gold Nanoparticles Using Bacterial Enzyme—In Vitro-In Silico Gastroplus® Simulation and Prediction

WA Mahdi, A Hussain, M Ramzan - Processes, 2020 - mdpi.com
The study investigated in situ biosynthesis of albumin capped 5-fluorouracil (5-FU) loaded
gold nanoparticles (NPs) using bacterial extract for enhanced efficacy against MCF-7 and in …

A combinatorial approach involving E. coli cytosine deaminase and 5-fluorocytosine-nanoparticles as an enzyme-prodrug therapeutic method for highly substrate …

H Horo, S Porathoor, R Anand, LM Kundu - Journal of Drug Delivery …, 2020 - Elsevier
Enzyme-prodrug combination is a recognized therapeutic strategy for the treatment of
cancer cells. Cytosine deaminases (CD) are non-mammalian proteins perceived to convert …

Nanoparticle-based macromolecule drug delivery to lungs

N Kumar, V Gautam, V Kumar, PK Maurya - … Chronic Inflammatory Lung …, 2020 - Elsevier
The pulmonary system is a unique drug delivery system as it offers large surface area, thin
layer of epithelia, and higher blood supply ensuring quick absorption of therapeutics. The …