[HTML][HTML] Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers: in vitro and in vivo study
CS Shi, KL Kuo, WC Lin, MS Chen, SH Liu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate
important biological processes and are a potential therapeutic target in many types of …
important biological processes and are a potential therapeutic target in many types of …
The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma
Renal cell carcinoma (RCC) is a major cancer of the kidney. The 5-year survival rate is
overall 74% and only 8% for Stage 4 cancers. Several agents including tyrosine kinase …
overall 74% and only 8% for Stage 4 cancers. Several agents including tyrosine kinase …
The NEDD8-activating enzyme inhibition with MLN4924 sensitizes human cancer cells of different origins to apoptosis and necroptosis
Objectives MLN4924 is an inhibitor of NEDD8-activating enzyme (NAE) that interferes with
the cullin-RING ubiquitin ligase complexes formation and the nuclear factor kappa B (NF-κB) …
the cullin-RING ubiquitin ligase complexes formation and the nuclear factor kappa B (NF-κB) …
[HTML][HTML] Neddylation-mediated Nedd4-2 activation regulates ubiquitination modification of renal NBCe1
J Tu, B Zhang, G Fang, W Chang, Y Zhao - Experimental Cell Research, 2020 - Elsevier
The sodium-coupled bicarbonate cotransporter 1 (NBCe1) plays an essential role in the
maintenance of acid-base homeostasis in the human body. However, little research has …
maintenance of acid-base homeostasis in the human body. However, little research has …
[图书][B] Pharmacologic Inhibition of Ubiquitin Activation as a Novel Therapeutic Strategy in Acute Myeloid Leukemia
SH Barghout - 2020 - search.proquest.com
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new
therapeutic approaches are required. One such potential therapeutic strategy is to target …
therapeutic approaches are required. One such potential therapeutic strategy is to target …