Toll-like receptor signaling in depression
Depression is one of the most prevalent, disabling, and costly mental illnesses currently
affecting over 300 million people worldwide. A subset of depressed patients display …
affecting over 300 million people worldwide. A subset of depressed patients display …
Signalling, sorting and scaffolding adaptors for Toll-like receptors
Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
Mild innate immune activation overrides efficient nanoparticle‐mediated RNA delivery
MP Lokugamage, Z Gan, C Zurla, J Levin… - Advanced …, 2020 - Wiley Online Library
Clinical mRNA delivery remains challenging, in large part because how physiology alters
delivery in vivo remains underexplored. For example, mRNA delivered by lipid nanoparticles …
delivery in vivo remains underexplored. For example, mRNA delivered by lipid nanoparticles …
Macrophage TLR4 and PAR2 signaling: role in regulating vascular inflammatory injury and repair
Macrophages play a central role in dictating the tissue response to infection and
orchestrating subsequent repair of the damage. In this context, macrophages residing in the …
orchestrating subsequent repair of the damage. In this context, macrophages residing in the …
Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production
H Metwally, T Tanaka, S Li, G Parajuli, S Kang… - Science …, 2020 - science.org
The lipopolysaccharide (LPS)–induced endocytosis of Toll-like receptor 4 (TLR4) is an
essential step in the production of interferon-β (IFN-β), which activates the transcription of …
essential step in the production of interferon-β (IFN-β), which activates the transcription of …
MIP-1α expression induced by co-stimulation of human monocytic cells with palmitate and TNF-α involves the TLR4-IRF3 pathway and is amplified by oxidative stress
S Sindhu, N Akhter, A Wilson, R Thomas, H Arefanian… - Cells, 2020 - mdpi.com
Metabolic inflammation is associated with increased expression of saturated free fatty acids,
proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage …
proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage …
Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase
AT Holdbrooks, KE Ankenbauer, J Hwang, SL Bellis - PLoS One, 2020 - journals.plos.org
The ST6Gal-I sialyltransferase, an enzyme that adds α2-6-linked sialic acids to N-
glycosylated proteins, regulates multiple immunological processes. However, the …
glycosylated proteins, regulates multiple immunological processes. However, the …
Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx–dependent pyroptosis in intestinal epithelial cells
Q Zhong, TI Roumeliotis, Z Kozik… - PLoS …, 2020 - journals.plos.org
Clustering of the enteropathogenic Escherichia coli (EPEC) type III secretion system (T3SS)
effector translocated intimin receptor (Tir) by intimin leads to actin polymerisation and …
effector translocated intimin receptor (Tir) by intimin leads to actin polymerisation and …
Oral exposure to 1, 4-dioxane induces hepatic inflammation in mice: the potential promoting effect of the gut microbiome
Q Zhou, L Jiang, J Qiu, Y Pan, RV Swanda… - Environmental …, 2020 - ACS Publications
1, 4-Dioxane is a widely used industrial solvent that has been frequently detected in aquatic
environments. However, the hepatotoxicity of long-term dioxane exposure at …
environments. However, the hepatotoxicity of long-term dioxane exposure at …
Sphingomyelin synthase activity affects TRIF-dependent signaling of Toll-like receptor 4 in cells stimulated with lipopolysaccharide
K Prymas, A Świątkowska, G Traczyk… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Bacterial lipopolysaccharide (LPS) is recognized by CD14 protein and the Toll-like receptor
(TLR) 4/MD2 complex localized in the plasma membrane of immune cells. TLR4 triggers two …
(TLR) 4/MD2 complex localized in the plasma membrane of immune cells. TLR4 triggers two …