Lymphatic flow: a potential target in sepsis-associated acute lung injury

C Wu, H Li, P Zhang, C Tian, J Luo… - Journal of …, 2020 - Taylor & Francis
Sepsis is life-threatening organ dysfunction caused by an imbalance in the body's response
to infection and acute lung injury (ALI) related to sepsis is a common complication. The rapid …

Effects of IFN‐γ on immune cell kinetics during the resolution of acute lung injury

JR Mock, MK Tune, CF Dial… - Physiological …, 2020 - Wiley Online Library
The immunologic responses that occur early in the acute respiratory distress syndrome
(ARDS) elicit immune‐mediated damage. The mechanisms underlying the resolution of …

Hesperetin ameliorates lipopolysaccharide‐induced acute lung injury via the miR‐410/SOX18 axis

J Dong, H Zhou, H Zhao, Y Zhao… - Journal of Biochemical …, 2020 - Wiley Online Library
Abstract Hesperetin (Hesp), a dihydroflavone, has a wide range of pharmacological
activities, including antioxidant, anti‐inflammatory, and antitumor effects, as well as …

Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury

J Wang, HY Li, ZB Su - Journal of Molecular Medicine, 2020 - Springer
Acute lung injury (ALI) is often associated with inflammation. Increasing evidence has
identified the role for ubiquitin-specific protease 7 (USP7) in activating the expression of …

[HTML][HTML] Role and mechanism of maresin-1 in acute lung injury induced by trauma-hemorrhagic shock

H Ma, S Mo, Q Yi, J Lai, H Liu, Z Shi - Medical Science Monitor …, 2020 - ncbi.nlm.nih.gov
Background It is reported that trauma hemorrhagic shock (THS) could resulted in organ
injury and is related to a high mortality rate. Maresin-1 (MaR1), a derived medium through …

Targeted antagonism of vascular endothelial growth factor reduces mortality of mice with acute respiratory distress syndrome

Z Zhang, D Lu, D Zhang, X Wang, Y Ming, Z Wu - Current Medical Science, 2020 - Springer
Acute respiratory distress syndrome (ARDS) is associated with a mortality of 45%. Our
previous research indicated that anti-vascular endothelial growth factor (VEGF) could …

[HTML][HTML] Лейтрагин повышает выживаемость животных в модели фатального острого респираторного дистресс-синдрома при профилактическом и лечебном …

ВН Каркищенко, ИА Помыткин, МТ Гасанов… - …, 2020 - cyberleninka.ru
Настоящая работа посвящена изучению эффектов лейтрагина, опиоидного пептида-
аналога эндогенного динорфина 1-6, на выживаемость животных в экспериментальной …

[HTML][HTML] Модель фатального острого поражения легких и острого респираторного дистресс-синдрома

ИА Помыткин, ВН Каркищенко, ЮВ Фокин… - …, 2020 - cyberleninka.ru
Настоящая работа посвящена разработке экспериментальной фатальной модели
острого поражения легких и острого респираторного дистресс-синдрома (ОРДС) на …

Can animal models really teach us anything about pneumonia? Pro

CJ Orihuela, UA Maus, JS Brown - European Respiratory …, 2020 - Eur Respiratory Soc
Despite highly effective antibiotics and intensive care support, the mortality associated with
pneumonia has not substantially decreased since the 1960s [1]. Hence, there remains a …

miR‐642a‐5p partially mediates the effects of lipopolysaccharide on human pulmonary microvascular endothelial cells via eEF2

L Fei, G Sun, Q You - FEBS Open bio, 2020 - Wiley Online Library
Inhalation or systemic administration of lipopolysaccharide (LPS) can induce acute
pulmonary inflammation and lung injury. The pulmonary vasculature is composed of …