Gastric cancer: a comprehensive review of current and future treatment strategies
RE Sexton, MN Al Hallak, M Diab, AS Azmi - Cancer and Metastasis …, 2020 - Springer
Gastric cancer remains a major unmet clinical problem with over 1 million new cases
worldwide. It is the fourth most commonly occurring cancer in men and the seventh most …
worldwide. It is the fourth most commonly occurring cancer in men and the seventh most …
[HTML][HTML] Targeting autophagy-related protein kinases for potential therapeutic purpose
H Xiang, J Zhang, C Lin, L Zhang, B Liu… - … Pharmaceutica Sinica B, 2020 - Elsevier
Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …
organelles mediated by lysosomes, plays a significant role in the quality control of …
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas
Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …
[HTML][HTML] A review of ULK1-mediated autophagy in drug resistance of cancer
L Liu, L Yan, N Liao, WQ Wu, JL Shi - Cancers, 2020 - mdpi.com
The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …
[HTML][HTML] Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer
Y Zhen, R Zhao, M Wang, X Jiang, F Gao, L Fu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Triple-negative breast cancer (TNBC) is one of the most prevalent neoplastic
diseases worldwide, but efficacious treatments for this pathological condition are still …
diseases worldwide, but efficacious treatments for this pathological condition are still …
[HTML][HTML] Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing
Axonal degeneration is a key and early pathological feature in traumatic and
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …
[HTML][HTML] Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation
M Alsaqati, VM Heine, AJ Harwood - Molecular autism, 2020 - Springer
Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder
resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised …
resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised …
The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target
ST Xue, K Li, Y Gao, LY Zhao, Y Gao, H Yi, JD Jiang… - Autophagy, 2020 - Taylor & Francis
Although macroautophagy/autophagy is involved in hepatocellular carcinoma (HCC)
initiation and development and has been identified as a mechanism of HCC therapy …
initiation and development and has been identified as a mechanism of HCC therapy …
Discovery of a novel dual-target inhibitor of ERK1 and ERK5 that induces regulated cell death to overcome compensatory mechanism in specific tumor types
G Wang, Y Zhao, Y Liu, D Sun, Y Zhen… - Journal of Medicinal …, 2020 - ACS Publications
ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some
circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon …
circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon …
[HTML][HTML] Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells
Y Liang, Y Jiang, X Jin, P Chen, Y Heng, L Cai… - Cell Communication and …, 2020 - Springer
Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our
previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 …
previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 …