Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers
M Kushnarev, IP Pirvulescu, KD Candido… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Neuropathic pain is a chronic condition that significantly affects the quality of life
of millions of people globally. Most of the pharmacologic treatments currently in use …
of millions of people globally. Most of the pharmacologic treatments currently in use …
Neurobiological activity of conotoxins via sodium channel modulation
Conotoxins (CnTX) are bioactive peptides produced by marine molluscs belonging to Conus
genus. The biochemical structure of these venomous peptides is characterized by a low …
genus. The biochemical structure of these venomous peptides is characterized by a low …
Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor
Voltage-gated sodium (NaV) channel subtypes, including NaV1. 7, are promising targets for
the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ …
the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ …
μ-conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNav1. 8
M Yang, M Zhou - Toxicon, 2020 - Elsevier
TsIIIA, the first μ-conotoxin from Conus tessulatus, can selectively inhibit rat tetrodotoxin-
resistant sodium channels. TsIIIA also shows potent analgesic activity in a mice hotplate …
resistant sodium channels. TsIIIA also shows potent analgesic activity in a mice hotplate …
Marine Drugs: A Source of Medicines for Neuroinflammatory Disorders
A Muthuraman, N Rishitha… - … Drug Molecules of …, 2020 - api.taylorfrancis.com
Neuroinflammation is due to the abnormal neurovascular system. In nervous tissue nerve,
the blood barrier is altered in pathological conditions of neuroinflammation which leads to …
the blood barrier is altered in pathological conditions of neuroinflammation which leads to …
Comparative Study on the Extraction of Total RNA from Different Tissue Parts of Cone Snail (Conns geographus)
Q Chen, C Peng, S Lin, B Gao - Agricultural Biotechnology, 2020 - search.proquest.com
Abstract & Objectives] This study was conducted to compare the quality of total RNA
extracted from diferent tissues of cone snail (Conus geographus). & Methods] The total RNA …
extracted from diferent tissues of cone snail (Conus geographus). & Methods] The total RNA …