The negative affect of protracted opioid abstinence: progress and perspectives from rodent models

L Welsch, J Bailly, E Darcq, BL Kieffer - Biological psychiatry, 2020 - Elsevier
Opioid use disorder (OUD) is characterized by the development of a negative emotional
state that develops after a history of long-term exposure to opioids. OUD represents a true …

Opioid and neuroHIV comorbidity–current and future perspectives

S Fitting, MP McRae, KF Hauser - Journal of Neuroimmune Pharmacology, 2020 - Springer
With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …

TMEM119 as a specific marker of microglia reaction in traumatic brain injury in postmortem examination

S Bohnert, A Seiffert, S Trella, M Bohnert… - International Journal of …, 2020 - Springer
The aim of the present study was a refined analysis of neuroinflammation including
TMEM119 as a useful microglia-specific marker in forensic assessments of traumatic causes …

Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents

C Du, ND Volkow, J You, K Park, CP Allen… - Molecular …, 2020 - nature.com
Cocaine-induced vasoconstriction reduces blood flow, which can jeopardize neuronal
function and in the prefrontal cortex (PFC) it may contribute to compulsive cocaine intake …

Cocaine-induced structural and functional impairments of the glymphatic pathway in mice

W Chen, P Huang, H Zeng, J Lin, Z Shi… - Brain, Behavior, and …, 2020 - Elsevier
The glymphatic system plays a central role in the clearance of extracellular wastes from the
brain. Cocaine exposure can lead to pathologies that affect the entire brain, resulting in …

Novel neuroprotective potential of crocin in neurodegenerative disorders: an illustrated mechanistic review

S Kermanshahi, G Ghanavati… - Neurochemical …, 2020 - Springer
Neurodegenerative disorders are characterized by mitochondrial dysfunction and
subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal …

Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time

HZ Rosa, RCS Barcelos, HJ Segat, K Roversi… - European …, 2020 - Elsevier
Addiction is a devastating worldwide disorder that requires effective and innovative
therapies. Physical exercise could be useful in addiction treatment because it shares a …

Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters

HZ Rosa, HJ Segat, RCS Barcelos, K Roversi… - Pharmacology …, 2020 - Elsevier
Psychostimulant drugs addiction is a chronic public health problem and individuals remain
susceptible to relapses increasing public expenses even after withdrawal and treatment. Our …

CNS vasculitis—an overview of this multiple sclerosis mimic: clinical and MRI implications

VL Jewells, RE Latchaw - Seminars in Ultrasound, CT and MRI, 2020 - Elsevier
This article discusses central nervous system vasculitis, a clinical and MRI mimic of multiple
sclerosis (MS). There is a paucity of discussion of vasculitis in the radiology literature, and …

Prison sentencing increases the risk of unemployment among illegal heroin users in Taiwan

CTC Lee, CM Huang, LC Chang, SW Wang… - … , Prevention, and Policy, 2020 - Springer
Background Previous studies have rarely explored the effect of type of sentencing on
employment status among illegal heroin users, therefore, we aims to examine the …