Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution

U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - ASPET
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

The relationship between serum copper and overweight/obesity: a meta-analysis

K Gu, X Li, W Xiang, X Jiang - Biological trace element research, 2020 - Springer
The relationship between serum copper (Cu) level and overweight/obesity remains
controversial. The purpose of this meta-analysis is to evaluate the relationship. A …

[HTML][HTML] Incendiary leptin

P Seoane-Collazo, N Martínez-Sánchez, E Milbank… - Nutrients, 2020 - mdpi.com
Leptin is a hormone released by adipose tissue that plays a key role in the control of energy
homeostasis through its binding to leptin receptors (LepR), mainly expressed in the …

Rare genetic forms of obesity: from gene to therapy

K Clément, H Mosbah, C Poitou - Physiology & behavior, 2020 - Elsevier
Monogenic non-syndromic obesity is characterized by severe early-onset obesity with
abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms …

[HTML][HTML] COVID-19-related anxiety disorder in Iraq during the pandemic: an online cross-sectional study

SK Karim, PH Taha, NMM Amin, HS Ahmed… - Middle East Current …, 2020 - Springer
Background The COVID-19 outbreak is an unprecedented global public health burden,
which popped up in China in late 2019 to early 2020 and distributed worldwide rapidly …

The blood-brain barrier interface in diabetes mellitus: dysfunctions, mechanisms and approaches to treatment

WA Banks - Current Pharmaceutical Design, 2020 - ingentaconnect.com
Diabetes mellitus (DM) is one of the most common diseases in the world. Among its effects
are an increase in the risk of cognitive impairment, including Alzheimer's disease, and blood …

Monogenic leptin deficiency in early childhood obesity

G ElSaeed, N Mousa, F El‐Mougy, M Hafez… - Pediatric …, 2020 - Wiley Online Library
Background Early childhood obesity is a public health problem worldwide. It affects different
aspects of physical and mental child's health. Identifying the etiologies, especially treatable …

[HTML][HTML] Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Z Ren, Y Liu, W Hong, X Pan, P Gong, Q Liu, G Zhou… - Molecular Brain, 2020 - Springer
Leptin, secreted by peripheral adipocytes, binds the leptin receptor (Lepr) in the
hypothalamus, thereby contributing to the regulation of satiety and body weight. Lepr is …

Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women

R Karim, HM Dang, HN Hodis, FZ Stanczyk… - Menopause, 2020 - journals.lww.com
Objective: Vasomotor flushing (hot flushes) is a common menopausal symptom experienced
by most women going through the menopausal transition; flushing continues for a variable …

Identification of short-chain pyroglutamyl peptides in Japanese salted fermented soy paste (miso) and their anti-obesity effect

S Shirako, Y Kojima, T Hasegawa… - Journal of Food …, 2020 - isnff-jfb.com
Miso, a paste of salted fermented soybean, is a seasoning used extensively in traditional
Japanese cuisine. Herein, pyroglutamyl peptides present in miso were identified by a liquid …