The genetics of asthma and the promise of genomics-guided drug target discovery

ZW El-Husseini, R Gosens, F Dekker… - The Lancet …, 2020 - thelancet.com
Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …

The airway epithelium—A central player in asthma pathogenesis

J Calvén, E Ax, M Rådinger - International Journal of Molecular Sciences, 2020 - mdpi.com
Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …

Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis

TA Olafsdottir, F Theodors, K Bjarnadottir… - Nature …, 2020 - nature.com
Asthma is one of the most common chronic diseases affecting both children and adults. We
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …

[HTML][HTML] Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

T Malachowski, A Hassel - Engineered Regeneration, 2020 - Elsevier
Nanotechnology has recently gained traction in the medical field as a method of targeted
delivery and timed release of therapeutic drugs. As interest in this field grows, design …

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa

A Laulajainen-Hongisto, A Lyly, T Hanif… - Clinical and translational …, 2020 - Springer
Genome wide association studies (GWASs) have revealed several airway disease-
associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic …

FUT2ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

TS Ahluwalia, AU Eliasen, A Sevelsted… - Nature …, 2020 - nature.com
Asthma with severe exacerbation is the most common cause of hospitalization among young
children. We aim to increase the understanding of this clinically important disease entity …

Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men

SH Lin, E Loftfield, JN Sampson, W Zhou, M Yeager… - Scientific Reports, 2020 - nature.com
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …

MicroRNA-30a targets ATG5 and attenuates airway fibrosis in asthma by suppressing autophagy

BB Li, Y Chen, F Pang - Inflammation, 2020 - Springer
Asthma is the most common chronic disease of childhood, chronic airway inflammation;
bronchial tissue fibrosis, is a pathological feature common to children asthma, and an …

Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study

H Sunadome, H Matsumoto, Y Izuhara… - Allergology …, 2020 - jstage.jst.go.jp
Background: Obesity affects the pathogenesis of various chronic diseases, including
asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in …

[HTML][HTML] Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

MA Portelli, FN Dijk, ME Ketelaar, N Shrine… - JCI insight, 2020 - ncbi.nlm.nih.gov
Abstract The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the
contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma …