The genetics of asthma and the promise of genomics-guided drug target discovery
Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
The airway epithelium—A central player in asthma pathogenesis
J Calvén, E Ax, M Rådinger - International Journal of Molecular Sciences, 2020 - mdpi.com
Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
TA Olafsdottir, F Theodors, K Bjarnadottir… - Nature …, 2020 - nature.com
Asthma is one of the most common chronic diseases affecting both children and adults. We
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …
[HTML][HTML] Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery
T Malachowski, A Hassel - Engineered Regeneration, 2020 - Elsevier
Nanotechnology has recently gained traction in the medical field as a method of targeted
delivery and timed release of therapeutic drugs. As interest in this field grows, design …
delivery and timed release of therapeutic drugs. As interest in this field grows, design …
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
A Laulajainen-Hongisto, A Lyly, T Hanif… - Clinical and translational …, 2020 - Springer
Genome wide association studies (GWASs) have revealed several airway disease-
associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic …
associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic …
FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
Asthma with severe exacerbation is the most common cause of hospitalization among young
children. We aim to increase the understanding of this clinically important disease entity …
children. We aim to increase the understanding of this clinically important disease entity …
Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
MicroRNA-30a targets ATG5 and attenuates airway fibrosis in asthma by suppressing autophagy
BB Li, Y Chen, F Pang - Inflammation, 2020 - Springer
Asthma is the most common chronic disease of childhood, chronic airway inflammation;
bronchial tissue fibrosis, is a pathological feature common to children asthma, and an …
bronchial tissue fibrosis, is a pathological feature common to children asthma, and an …
Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study
H Sunadome, H Matsumoto, Y Izuhara… - Allergology …, 2020 - jstage.jst.go.jp
Background: Obesity affects the pathogenesis of various chronic diseases, including
asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in …
asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in …
[HTML][HTML] Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
MA Portelli, FN Dijk, ME Ketelaar, N Shrine… - JCI insight, 2020 - ncbi.nlm.nih.gov
Abstract The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the
contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma …
contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma …